Fatal outcome of pyoderma gangrenosum with multiple organ involvement and partially responding to Infliximab

• Authors: Stefan Drinda , Peter Oelzner , Carolina Codina Canet , Martin Kaatz , Gunter Wolf , Gert Hein
• Languages of publication: EN

Abstracts

EN

Pyoderma gangrenosum is an inflammatory dermatosis of uncertain etiology, often associated with chronic inflammatory bowel or rheumatoid disease. It predominantly affects the skin. A systemic organ involvement caused by aseptic neutrophilic abscesses, however, fundamentally influences the prognosis.A patient with idiopathic pyoderma gangrenosum insufficiently responded to a conventional immune suppressive therapy and the disease proceeded aggressively. During treatment with Infliximab, partial remission was achieved intermediately. However, a recurring endocarditis, led to a lethal outcome of this patient.

Keywords

EN

Pyoderma gangrenosum; extracutaneous manifestation; cardiac involvement; Infliximab

• Publisher: De Gruyter Open
• Journal: Open Medicine
• Year: 2006
• Volume: 1
• Issue: 3
• Pages: 306-312

Dates

published

1 - 9 - 2006

online

23 - 8 - 2006

Contributors

author

Stefan Drinda

• Department of Internal Medicine III, Friedrich Schiller University Jena, D 07740, Jena, Germany

author

Peter Oelzner

• Department of Internal Medicine III, Friedrich Schiller University Jena, D 07740, Jena, Germany

author

Carolina Codina Canet

• Department of Pathology, Friedrich Schiller University Jena, D 07740, Jena, Germany

author

Martin Kaatz

• Department of Dermatology, Friedrich Schiller University Jena, D 07743, Jena, Germany

author

Gunter Wolf

• Department of Internal Medicine III, Friedrich Schiller University Jena, D 07740, Jena, Germany

author

Gert Hein

• Department of Internal Medicine III, Friedrich Schiller University Jena, D 07740, Jena, Germany

References

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Identifiers

DOI

10.2478/s11536-006-0024-9