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Journal

2006 | 1 | 1 | 87-98

Article title

Multiple primary malignant neoplasms - case report

Content

Title variants

Languages of publication

EN

Abstracts

EN
The synchronous occurence of primary carcinomas of endometrium and ovary is well recognized. Malignant peripheral nerve sheath tumours (MPNSTs) may also rarely occur in patients diagnosed with malignancies of the female genital tract. We report a rare case of synchronous primary carcinomas of endometrium and ovary, followed by a metachronous retroperitoneal MPNST. Ascites cytology and endometrial biopsy, followed by hysterectomy and bilateral adnexectomy, were performed to remove the synchronous tumors. Histology was suggestive of synchronous endometrial endometrioid carcinoma and ovarian mucinous adenocarcinoma. After the removal of the retroperitoneal tumor, a MPNST was diagnosed by immunohistochemistry. The patient developed two consecutive vaginal tumors diagnosed as metastases of the previously diagnosed endometrial carcinoma. Although synchronous tumors of endometrium and ovary were relatively early staged and consequently had a favorable prognosis, subsequently occuring implants along the lower genital tract and the metachronous MPNST added up to a poor prognosis.

Publisher

Journal

Year

Volume

1

Issue

1

Pages

87-98

Physical description

Dates

published
1 - 3 - 2006
online
1 - 3 - 2006

Contributors

  • Pathology Department, University of Medicine and Pharmacy Iasi, Romania
author
  • Pathology Department, University of Medicine and Pharmacy Iasi, Romania
author
  • Pathology Laboratory, Military Hospital Iasi, Romania
  • Obstetrics and Gynecology Department, University of Medicine and Pharmacy Iasi, Romania
  • Obstetrics and Gynecology Department, University of Medicine and Pharmacy Iasi, Romania
  • Pathology Department, University of Medicine and Pharmacy Iasi, Romania

References

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  • [2] C.D.M. Fletcher (Ed.): Diagnostic Histopathology of Tumors, Vol. 2, Churchill Livingstone, Edinburgh, 2000.
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  • [6] K.R. Lee and R.H. Young: “The distinction between primary and metastatic mucinous carcinomas of the ovary: gross and histologic findings in 50 cases”, Am. J. Surg. Pathol., Vol. 27, (2003), pp. 281–293. http://dx.doi.org/10.1097/00000478-200303000-00001[Crossref]
  • [7] R.L. Levine, C.B. Cargile, M.S. Blazes, B. van Rees, R.J. Kurman and L.H. Ellenson: “PTEN mutations and microsatellite instability in complex atypical hyperplasia, a precursor lesion to uterine endometrioid carcinoma”, Cancer Res., Vol. 58, (1998), pp. 3254–3258.
  • [8] M. Mandai, I. Konishi, H. Kuroda, T. Komatsu, S. Yamamoto, K. Nanbu, K. Matsushita, M. Fukumoto, H. Yamabe and T. Mori: “Heterogenous distribution of K-ras mutated epithelia in mucinous ovarian tumors with special reference to histopathology”, Hum. Pathol., Vol. 29, (1998), pp. 34–40. http://dx.doi.org/10.1016/S0046-8177(98)90387-2[Crossref]
  • [9] C. Mawrin, E. Kirches, C. Boltze, K. Dietzmann, A. Roessner and R. Schneider-Stock: “Immunohistochemical and molecular analysis of p53, RB, and PTEN in malignant peripheral nerve sheath tumors”, Virchows Arch Springer-Verlag, Vol. 440(6), (2002), pp. 610–615. http://dx.doi.org/10.1007/s00428-001-0550-4
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  • [12] R.R. Raju, W.R. Hart, D.K. Magnuson, J.R. Reid and D.G. Rogers: “Genital tract tumors in Proteus syndrome: report of a case of bilateral paraovarian endometrioid cystic tumors of borderline malignancy and review of the literature”, Mod. Pathol., Vol. 15(2), (2002), pp. 172–180. http://dx.doi.org/10.1038/modpathol.3880510[Crossref]
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Document Type

Publication order reference

Identifiers

YADDA identifier

bwmeta1.element.-psjd-doi-10_2478_s11536-006-0004-0
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