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2006 | 1 | 1 | 2-11
Article title

Changes of the expression of insulin-like growth factor 1 and its two receptors in the periphery of the developing lung are parallel to ultrastructural capillary changes during perinatal period

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EN
Abstracts
EN
Insulin-like growth factor type 1 (IGF-1) belongs to the peptide hormones which regulate cell proliferation and differentiation as well as angiogenesis.The aim of the present study was the quantitative evaluation of immuohistochemical (IH) expression of IGF-1 and its two receptors (IGF-1Rα and IGF-1Rβ) parallel to changes of capillary lumen/whole capillary area (L/W) ratio during the perinatal period.Tissue samples from lungs from 19-, and 21-day fetuses as well as 1-, 3-, 5-day old newborns were processed for frozen sections that were used for IH staining and then used for quantitative analysis of antigens expression. In parallel, tissue samples were processed for transmission electron microscopy and used for capillaries morphometry. Our results were statistically evaluated.We found that the expression of IGF-1 in the peripheral part of the developing lung has a peak at the moment of birth when changes of vascular structure were reflected by L/W ratio. This is followed by the peak expression of the IGF-1Rα, but not of the IGF-1Rβ.
Publisher

Journal
Year
Volume
1
Issue
1
Pages
2-11
Physical description
Dates
published
1 - 3 - 2006
online
1 - 3 - 2006
Contributors
  • Chair and Department of Clinical Pathomorphology, Poznan University of Medical Sciences, 60-355, Poznan, Poland, amars@amp.edu.pl
  • Chair and Department of Clinical Pathomorphology, Poznan University of Medical Sciences, 60-355, Poznan, Poland
author
  • Department of Pathology, Oita Medical University, Oita, Japan
  • Chair and Department of Clinical Pathomorphology, Poznan University of Medical Sciences, 60-355, Poznan, Poland
  • Intensive Care Unit, Collegium Medicum Jagiellonian University, Kraków, Poland
  • Department of Pathology, Oita Medical University, Oita, Japan
References
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Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.-psjd-doi-10_2478_s11536-006-0003-1
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