Unusual case of double acute intoxication with tamoxifen complicated by miscarriage

• Authors: Jacek Sein Anand , Zygmunt Chodorowski , Roman Korolkiewicz , Dorota Klimaszyk , Magdalena Łukasik-Głębocka
• Languages of publication: EN

Abstracts

EN

Background: A 24-year-old female had attempted suicide twice, at the age of 20 and 24, using tamoxifen.Case report: Subsequent to the first acute intoxication a development of bilateral ovarian cysts was observed. Cysts regressed spontaneously within 8 weeks. Five weeks after the second suicidal attempt, pregnant patient (15 weeks of gestation) was admitted to the hospital with vaginal bleeding and suspicion of miscarriage. The autopsy of the fetus did not reveal any gross abnormalities, whereas the microscopic examination demonstrated numerous foci of necrosis in the placental decidua. Other fetal membranes as well as the umbilical cord were normal.Conclusions:1.Acute intoxication with tamoxifen may be connected with the formation of follicular ovarian cysts.2.During pregnancy, intoxication with tamoxifen, may result in delayed miscarriage.

Keywords

EN

Tamoxifen; acute intoxication; pregnancy; miscarriage

• Publisher: De Gruyter Open
• Journal: Open Medicine
• Year: 2006
• Volume: 1
• Issue: 1
• Pages: 99-102

Dates

published

1 - 3 - 2006

online

1 - 3 - 2006

Contributors

author

Jacek Sein Anand

• Clinic of Internal Medicine and Acute Poisonings, Medical University, Gdańsk, Poland

author

Zygmunt Chodorowski

• Clinic of Internal Medicine and Acute Poisonings, Medical University, Gdańsk, Poland

author

Roman Korolkiewicz

• Department of Pharmacology, Medical University, Gdańsk, Poland

author

Dorota Klimaszyk

author

Magdalena Łukasik-Głębocka

• Department of Toxicology and Internal Diseases, F. Raszeja Hospital, Poznań, Poland

References

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Identifiers

DOI

10.2478/s11536-006-0002-2