Self-regulating genes. Exact steady state solution by using Poisson representation

• Authors: István Sugár , István Simon
• Languages of publication: EN

Abstracts

EN

Systems biology studies the structure and behavior of complex gene regulatory networks. One of its aims is to develop a quantitative understanding of the modular components that constitute such networks. The self-regulating gene is a type of auto regulatory genetic modules which appears in over 40% of known transcription factors in E. coli. In this work, using the technique of Poisson Representation, we are able to provide exact steady state solutions for this feedback model. By using the methods of synthetic biology (P.E.M. Purnick and Weiss, R., Nature Reviews, Molecular Cell Biology, 2009, 10: 410–422) one can build the system itself from modules like this.

Keywords

EN

genetics; master equations; Poisson representation; probability distribution

• Publisher: De Gruyter Open
• Journal: Open Physics
• Year: 2014
• Volume: 12
• Issue: 9
• Pages: 615-627

Dates

published

1 - 9 - 2014

online

31 - 7 - 2014

Contributors

author

István Sugár

• Department of Neurology and Center for Translational Systems Biology, Ichan School of Medicine at Mount Sinai, New York, NY, 10029, USA

author

István Simon

• Institute of Enzymology, Research Center for Natural Sciences, Hungarian Academy of Sciences, Budapest, Hungary

References

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Identifiers

DOI

10.2478/s11534-014-0497-0