This paper deals with the boundary layer flow and heat transfer of nanofluids over a stretching wedge with velocity-slip boundary conditions. In this analysis, Hall effect and Joule heating are taken into consideration. Four different types of water-base nanofluids containing copper (Cu), silver (Ag), alumina (Al2O3), and titania (TiO2) nanoparticles are analyzed. The partial differential equations governing the flow and temperature fields are converted into a system of nonlinear ordinary differential equations using a similarity transformation. The resulting similarity equations are then solved by using the shooting technique along with the fourth order Runge-Kutta method. The effects of types of nanoparticles, the volume fraction of nanoparticles, the magnetic parameter, the Hall parameter, the wedge angle parameter, and the velocityslip parameter on the velocity and temperature fields are discussed and presented graphically, respectively.