Analytical investigation of various regimes of retrograde trafficking of neurotropic viruses in axons

• Authors: Andrey Kuznetsov
• Languages of publication: EN

Abstracts

EN

A model of retrograde axonal transport of neurotropic viruses is developed. The model accounts for active viral transport by dynein motors as well as for passive transport by diffusion; the destruction of the virus as it propagates toward the neuron soma is modeled utilizing a first-order decay rate process. The effect of a limited time during which the axonal synapse is exposed to the virus is incorporated. An analytical solution is obtained. The obtained solution makes it possible to identify four different regimes of viral transport in the axon that correspond to the following situations: (1) Small viral diffusivity and small rate of viral destruction; (2) Large viral diffusivity and small rate of viral destruction; (3) Small viral diffusivity and large rate of viral destruction; (4) Large viral diffusivity and large rate of viral destruction. Characteristic features of these regimes are discussed.

Keywords

EN

neurotropic virus; retrograde axonal transport; molecular motors; virus trafficking

• Publisher: De Gruyter Open
• Journal: Open Physics
• Year: 2011
• Volume: 9
• Issue: 5
• Pages: 1372-1378

Dates

published

1 - 10 - 2011

online

15 - 9 - 2011

Contributors

author

Andrey Kuznetsov

• Dept. of Mechanical and Aerospace Engineering, North Carolina State University, Campus Box 7910, Raleigh, NC, 27695-7910, USA

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Identifiers

DOI

10.2478/s11534-011-0051-2