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Journal
2011 | 9 | 5 | 1372-1378
Article title

Analytical investigation of various regimes of retrograde trafficking of neurotropic viruses in axons

Content
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EN
Abstracts
EN
A model of retrograde axonal transport of neurotropic viruses is developed. The model accounts for active viral transport by dynein motors as well as for passive transport by diffusion; the destruction of the virus as it propagates toward the neuron soma is modeled utilizing a first-order decay rate process. The effect of a limited time during which the axonal synapse is exposed to the virus is incorporated. An analytical solution is obtained. The obtained solution makes it possible to identify four different regimes of viral transport in the axon that correspond to the following situations: (1) Small viral diffusivity and small rate of viral destruction; (2) Large viral diffusivity and small rate of viral destruction; (3) Small viral diffusivity and large rate of viral destruction; (4) Large viral diffusivity and large rate of viral destruction. Characteristic features of these regimes are discussed.
Publisher

Journal
Year
Volume
9
Issue
5
Pages
1372-1378
Physical description
Dates
published
1 - 10 - 2011
online
15 - 9 - 2011
Contributors
  • Dept. of Mechanical and Aerospace Engineering, North Carolina State University, Campus Box 7910, Raleigh, NC, 27695-7910, USA, avkuznet@eos.ncsu.edu
References
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Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.-psjd-doi-10_2478_s11534-011-0051-2
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