Effect of cytoskeletal element degradation on merging of concentration waves in slow axonal transport

• Authors: Andrey Kuznetsov , Andriy Avramenko , Dmitry Blinov
• Languages of publication: EN

Abstracts

EN

The aim of this paper is to investigate, by means of a numerical simulation, the effect of the half-life of cytoskeletal elements (CEs) on superposition of several waves representing concentrations of running, pausing, and off-track anterograde and retrograde CE populations. The waves can be induced by simultaneous microinjections of radiolabeled CEs in different locations in the vicinity of a neuron body; alternatively, the waves can be induced by microinjecting CEs at the same location several times, with a time interval between the injections. Since the waves spread out as they propagate downstream, unless their amplitude decreases too fast, they eventually superimpose. As a result of superposition and merging of several waves, for the case with a large half-life of CEs, a single wave is formed. For the case with a small half-life the waves vanish before they have enough time to merge.

Keywords

EN

molecular motors; neurons; axons; slow axonal transport; stop-and-go hypothesis; numerical modeling

• Publisher: De Gruyter Open
• Journal: Open Physics
• Year: 2011
• Volume: 9
• Issue: 4
• Pages: 898-908

Dates

published

1 - 8 - 2011

online

30 - 4 - 2011

Contributors

author

Andrey Kuznetsov

• Dept. of Mechanical and Aerospace Engineering, North Carolina State University, Campus Box 7910, Raleigh, NC, 27695-7910, USA

author

Andriy Avramenko

• Institute of Engineering Thermophysics, National Academy of Sciences, Kiev, Ukraine

author

Dmitry Blinov

• Institute of Engineering Thermophysics, National Academy of Sciences, Kiev, Ukraine

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Identifiers

DOI

10.2478/s11534-010-0116-7