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Journal
2011 | 9 | 4 | 898-908
Article title

Effect of cytoskeletal element degradation on merging of concentration waves in slow axonal transport

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EN
Abstracts
EN
The aim of this paper is to investigate, by means of a numerical simulation, the effect of the half-life of cytoskeletal elements (CEs) on superposition of several waves representing concentrations of running, pausing, and off-track anterograde and retrograde CE populations. The waves can be induced by simultaneous microinjections of radiolabeled CEs in different locations in the vicinity of a neuron body; alternatively, the waves can be induced by microinjecting CEs at the same location several times, with a time interval between the injections. Since the waves spread out as they propagate downstream, unless their amplitude decreases too fast, they eventually superimpose. As a result of superposition and merging of several waves, for the case with a large half-life of CEs, a single wave is formed. For the case with a small half-life the waves vanish before they have enough time to merge.
Publisher

Journal
Year
Volume
9
Issue
4
Pages
898-908
Physical description
Dates
published
1 - 8 - 2011
online
30 - 4 - 2011
Contributors
  • Dept. of Mechanical and Aerospace Engineering, North Carolina State University, Campus Box 7910, Raleigh, NC, 27695-7910, USA, avkuznet@eos.ncsu.edu
  • Institute of Engineering Thermophysics, National Academy of Sciences, Kiev, Ukraine
author
  • Institute of Engineering Thermophysics, National Academy of Sciences, Kiev, Ukraine
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Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.-psjd-doi-10_2478_s11534-010-0116-7
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