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2014 | 12 | 10 | 994-1007
Article title

Analytical methods for determination of benzodiazepines. A short review

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Abstracts
EN
Benzodiazepines (BDZs) are generally commonly used as anxiolytic and/or hypnotic drugs as a ligand of the GABAA-benzodiazepine receptor. Moreover, some of benzodiazepines are widely used as an anti-depressive and sedative drugs, and also as anti-epileptic drugs and in some cases can be useful as an adjunct treatment in refractory epilepsies or anti-alcoholic therapy. High-performance liquid chromatography (HPLC) methods, thin-layer chromatography (TLC) methods, gas chromatography (GC) methods, capillary electrophoresis (CE) methods and some of spectrophotometric and spectrofluorometric methods were developed and have been extensively applied to the analysis of number of benzodiazepine derivative drugs (BDZs) providing reliable and accurate results. The available chemical methods for the determination of BDZs in biological materials and pharmaceutical formulations are reviewed in this work.
Publisher

Journal
Year
Volume
12
Issue
10
Pages
994-1007
Physical description
Dates
published
1 - 10 - 2014
online
15 - 5 - 2014
Contributors
  • Collegium Medicum of Nicolaus Copernicus University
author
  • Collegium Medicum of Nicolaus Copernicus University
author
  • Collegium Medicum of Nicolaus Copernicus University
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bwmeta1.element.-psjd-doi-10_2478_s11532-014-0551-1
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