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Journal
2014 | 12 | 9 | 962-967
Article title

Controlled release of amoxicillin from bacterial cellulose membranes

Content
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Languages of publication
EN
Abstracts
EN
Bacterial cellulose (BC), a natural polymer with unique physical and mechanical properties, has several applications in the biomedical field, including drug loading and controlled drug delivery. For this study, a Box-Behnken experimental design was employed as a statistical tool to optimize the release of a model drug, amoxicillin, from BC membranes. Independent variables studied were the concentration of the drug (X1), the concentration of glycerol (X2) and the concentration of a permeation enhancer (X3). From the variables studied, drug concentration had the highest effect on drug release. Among the other independent variables, th linear and quadratic X2 terms, the linear X3 term and the interaction term X2X3 were found to affect the release of amoxicillin from bacterial cellulose membranes.
Publisher
Journal
Year
Volume
12
Issue
9
Pages
962-967
Physical description
Dates
published
1 - 9 - 2014
online
1 - 5 - 2014
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Document Type
Publication order reference
YADDA identifier
bwmeta1.element.-psjd-doi-10_2478_s11532-014-0541-3
Identifiers
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