Synthesis, characterization and controlled toxicity of a novel hybrid material based on cisplatin and docetaxel

• Authors: Mariana Prodana , Adriana Voiculet , Sorina Garea , Mihaela Radu , Horia Iovu , Ioana Demetrescu , Anca Dinischiotu
• Languages of publication: EN

Abstracts

EN

This paper is focused on the synthesis and characterization of a novel hybrid material based on cisplatin and docetaxel-loaded functionalized simultanously carbon nanotubes able to be used in cancer therapy as drug delivery system with controlled toxicity. This material was physico-chemically investigated by determining the structure, as evidenced by Fourier transform infrared (FTIR) spectroscopy, transmission electronmicroscopy (TEM) and its stability was studied with the aid of thermogravimetric analysis (TGA). The amount of platinum ions released into the solution of simulated body fluid (SBF) was highlighted by coupled plasma mass spectrometry (ICP-MS). Toxicology experiments were performed with MDA-MB 231 breast cancer epithelial cells. The performance of the new drug delivery hybrid material was compared with functionalised carbon nanotubes with therapeutic agents functionalized with a single therapeutic agent.

Keywords

EN

Carbon nanotubes; TGA; Functionalization; Drug; Cell viability

• Publisher: De Gruyter Open
• Journal: Open Chemistry
• Year: 2014
• Volume: 12
• Issue: 10
• Pages: 1008-1015

Dates

published

1 - 10 - 2014

online

15 - 5 - 2014

Contributors

author

Mariana Prodana

• Polytechnic University of Bucharest

author

Adriana Voiculet

• Polytechnic University of Bucharest

author

Sorina Garea

• Polytechnic University of Bucharest

author

Mihaela Radu

• University of Bucharest

author

Horia Iovu

• Polytechnic University of Bucharest

author

Ioana Demetrescu

• Polytechnic University of Bucharest

author

Anca Dinischiotu

• University of Bucharest

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Identifiers

DOI

10.2478/s11532-014-0536-0