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Journal
2013 | 11 | 12 | 2134-2143
Article title

Synthesis, characterization and bioevaluation of irinotecan-collagen hybrid materials for biomedical applications as drug delivery systems in tumoral treatments

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EN
Abstracts
EN
The purpose of the present study is the preparation and characterization of collagen/antitumor drug hybrids as drug delivery systems. Materials used for obtaining collagen-based drug delivery systems were collagen type I (Coll) as matrix and irinotecan (I) as hydrophilic active substances. After incorporation of I into Coll in differing ratios, the obtained hybrid materials (Coll/I) could be used according to our results as potential drug delivery systems in medicine for the topical (local) treatment of cancerous tissues or bone. The released amount of I varies with amount of Coll from hybrid materials: the higher, the slower the release amount of irinotecan transferred is in the first 6 hours. The in vitro citotoxicity demonstrates an antitumoral activity of the obtained hybrid materials and their potential use for biomedical applications as drug delivery systems in tumoral treatments. [...]
Publisher

Journal
Year
Volume
11
Issue
12
Pages
2134-2143
Physical description
Dates
published
1 - 12 - 2013
online
26 - 9 - 2013
Contributors
  • Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Material Science, Politehnica University of Bucharest, 011061, Bucharest, Romania
  • Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Material Science, Politehnica University of Bucharest, 011061, Bucharest, Romania
  • Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Material Science, Politehnica University of Bucharest, 011061, Bucharest, Romania, cghitulica@yahoo.com
author
  • Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Material Science, Politehnica University of Bucharest, 011061, Bucharest, Romania
  • Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Material Science, Politehnica University of Bucharest, 011061, Bucharest, Romania
  • S. Nicolau Institute of Virology, 030304, Bucharest, Romania
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Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.-psjd-doi-10_2478_s11532-013-0341-1
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