Differential pulse adsorptive stripping voltammetric determination of methotrexate using a functionalized carbon nanotubes-modified glassy carbon electrode

• Authors: Geiser Oliveira , Bruno Janegitz , Valtencir Zucolotto , Orlando Fatibello-Filho
• Languages of publication: EN

Abstracts

EN

A glassy carbon electrode (GC) containing multiwalled functionalized carbon nanotubes (MWCNTs) immobilized within a dihexadecylhydrogenphosphate film (DHP) is proposed as a nanostructured platform for determination of methotrexate (MTX) concentration (a drug used in cancer treatment) using differential pulse adsorptive stripping voltammetry (DPAdSV). The voltammograms for a MTX solution using MWCNTs-DHP/GC electrode presented an oxidation peak potential at 0.98 V vs. Ag/AgCl (3.0 mol L−1 KCl) in a 0.1 mol L−1 sulphuric acid. The apparent heterogeneous electron transfer rate constant of 0.46 s−1 was calculated. The recovery area of 2.62×10−9 mol cm2 was also obtained. Under the optimal experimental conditions, the analytical curve was linear in the MTX concentration range from 5.0×10−8 to 5.0×10−6 mol L−1, with a detection limit of 3.3×10−8 mol L−1. The MWCNTs-DHP/GC electrode can be easily prepared and was applied for the determination of MTX in pharmaceutical formulations, with results similar to those obtained using a high-performance liquid chromatography comparative method. [...]

Keywords

EN

Methotrexate determination; Multi-walled carbon nanotubes (MWCNTs); Dihexadecylhydrogenphosphate (DHP); Differential pulse adsorptive stripping voltammetry (DPAdSV); Electrochemical sensor

• Publisher: De Gruyter Open
• Journal: Open Chemistry
• Year: 2013
• Volume: 11
• Issue: 11
• Pages: 1837-1843

Dates

published

1 - 11 - 2013

online

25 - 8 - 2013

Contributors

author

Geiser Oliveira

• Department of Chemistry, Center for Science and Technology, Federal University of São Carlos, P. Box 676, 13560-970, São Carlos - SP, Brazil

author

Bruno Janegitz

• Nanomedicine and Nanotoxicology Group, São Carlos Institute of Physics, University of São Paulo, 13566-590, São Carlos - SP, Brazil

author

Valtencir Zucolotto

• Nanomedicine and Nanotoxicology Group, São Carlos Institute of Physics, University of São Paulo, 13566-590, São Carlos - SP, Brazil

author

Orlando Fatibello-Filho

• Department of Chemistry, Center for Science and Technology, Federal University of São Carlos, P. Box 676, 13560-970, São Carlos - SP, Brazil

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Identifiers

DOI

10.2478/s11532-013-0305-5