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Journal
2013 | 11 | 9 | 1431-1438
Article title

Azo-polysiloxane micelles charged with nifedipine

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EN
Abstracts
EN
Abstract One recent aspect of the research study on polymers is their capability to respond to external stimuli. Of importance are photosensitive polymers due to their application in drug delivery systems, sensors, therapeutic devices or optoelectronic switches. The present paper focuses on the azo-polysiloxane micelles capacity charged with hydrophobic drugs, such as nifedipine. Azo-polysiloxanes modified with quaternary ammonium groups and which are capable to generate photo-sensitive micelles were synthesized and characterized by 1H-NMR, UV-VIS and fluorescence spectroscopy. The critical concentration of the micellar aggregation (CCA) was evaluated as was the nifedipine embedding capacity. The CCA values were influenced only by the hydrophobic/hydrophilic balance and not by the chemical structure of the quaternary ammonium groups. The disaggregation capacity of the micelles under UV irradiation was investigated as well, and the best results were obtained for the samples with higher azobenzene content. The DLS measurements evidenced micelles diameters situated in the optimum range domain (70–130 nm). The capacity to incorporate nifedipine inside the micelles was demonstrated. The micelles proved to be stable in time, 21 days after preparation with the diameter having constant values. Graphical abstract [...]
Publisher

Journal
Year
Volume
11
Issue
9
Pages
1431-1438
Physical description
Dates
published
1 - 9 - 2013
online
29 - 6 - 2013
Contributors
  • Department of Natural and Synthetic Polymers, “Gheorghe Asachi” Technical University of Iasi, 700050, Iasi, Romania
author
  • Department of Natural and Synthetic Polymers, “Gheorghe Asachi” Technical University of Iasi, 700050, Iasi, Romania
  • Centre of Advanced Research in Bionanoconjugates and Biopolymers, “Petru Poni”, Institute of Macromolecular Chemistry of Romanian Academy, 700487, Iasi, Romania
  • Centre of Advanced Research in Bionanoconjugates and Biopolymers, “Petru Poni”, Institute of Macromolecular Chemistry of Romanian Academy, 700487, Iasi, Romania
  • Department of Natural and Synthetic Polymers, “Gheorghe Asachi” Technical University of Iasi, 700050, Iasi, Romania, nhurduc@ch.tuiasi.ro
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Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.-psjd-doi-10_2478_s11532-013-0279-3
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