Characterization of polymeric system for cisplatin delivery - analytical methods for Pt determination

• Authors: Ekaterina Stoyanova , Irina Karadjova , Methody Karadjov , Neli Koseva
• Languages of publication: EN

Abstracts

EN

Abstract Cis-diamminedichloroplatinum(II) (cisplatin) was immobilized in a star-shaped polymer carrier. In order to define whether this polymer could be used as a drug delivery system for cisplatin, its characteristics, e.g. loading efficiency and release profile of cisplatin from the polymer in phosphate buffered saline (PBS), have to be assessed, and hence an appropriate analytical procedure for precise and reliable determination of Pt(II) must be established. Optimal instrumental parameters for Pt measurement by commonly used atomic spectrometric methods ETAAS and ICP-OES in various examined media were defined. Matrix interferences observed that were related to both techniques were evaluated, and analytical figures of merit were compared and critically discussed. Graphical abstract [...]

Keywords

EN

Pt; ETAAS; ICP-OES; Polymer drug; Phosphate buffered saline

• Publisher: De Gruyter Open
• Journal: Open Chemistry
• Year: 2013
• Volume: 11
• Issue: 9
• Pages: 1548-1553

Dates

published

1 - 9 - 2013

online

29 - 6 - 2013

Contributors

author

Ekaterina Stoyanova

author

Irina Karadjova

• Faculty of Chemistry and Pharmacy, Sofia University “St. Kliment Ohridski, 1164, Sofia, Bulgaria

author

Methody Karadjov

• Geological Institute, Bulgarian Academy of Sciences, 1113, Sofia, Bulgaria

author

Neli Koseva

• Institute of Polymers, Bulgarian Academy of Sciences, 1113, Sofia, Bulgaria

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Identifiers

DOI

10.2478/s11532-013-0278-4