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2013 | 11 | 9 | 1548-1553
Article title

Characterization of polymeric system for cisplatin delivery - analytical methods for Pt determination

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EN
Abstracts
EN
Abstract Cis-diamminedichloroplatinum(II) (cisplatin) was immobilized in a star-shaped polymer carrier. In order to define whether this polymer could be used as a drug delivery system for cisplatin, its characteristics, e.g. loading efficiency and release profile of cisplatin from the polymer in phosphate buffered saline (PBS), have to be assessed, and hence an appropriate analytical procedure for precise and reliable determination of Pt(II) must be established. Optimal instrumental parameters for Pt measurement by commonly used atomic spectrometric methods ETAAS and ICP-OES in various examined media were defined. Matrix interferences observed that were related to both techniques were evaluated, and analytical figures of merit were compared and critically discussed. Graphical abstract [...]
Publisher

Journal
Year
Volume
11
Issue
9
Pages
1548-1553
Physical description
Dates
published
1 - 9 - 2013
online
29 - 6 - 2013
Contributors
  • Geological Institute, Bulgarian Academy of Sciences, 1113, Sofia, Bulgaria
author
  • Institute of Polymers, Bulgarian Academy of Sciences, 1113, Sofia, Bulgaria
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Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.-psjd-doi-10_2478_s11532-013-0278-4
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