Direct determination of enantiomeric enrichment of chiral, underivatized aminophosphonic acids - useful for enantioselective bioconversion results evaluation

• Authors: Kinga Kozyra , Magdalena Klimek-Ochab , Małgorzata Brzezińska-Rodak , Ewa Żymańczyk-Duda
• Languages of publication: EN

Abstracts

EN

Abstract The possibility of applying 31P NMR spectroscopy for the determination of the enantiomeric excess of the racemic mixture of non-derivatized aminophosphonic acids with small side chains has been investigated. It is proven, that the effectiveness of the application of a chiral solvating agent strongly depends on the concentration of applied shift reagent and on the pH of the particular experiment. Effectual resolution protocols are elaborated for following phosphonic acids: 1-aminoethanephosphonic acid, 1-amino-2-methylpropanephosphonic acid, 1-aminophenylmethanephosphonic acid, 1-aminophenylmethane-phosphonic acid and 1-amino-2-phenylethanephosphonic acid. Graphical abstract [...]

Keywords

EN

NMR; Aminophosphonic acid; Enantiomeric excess; Chiral solvating agent

• Publisher: De Gruyter Open
• Journal: Open Chemistry
• Year: 2013
• Volume: 11
• Issue: 9
• Pages: 1542-1547

Dates

published

1 - 9 - 2013

online

29 - 6 - 2013

Contributors

author

Kinga Kozyra

• Department of Bioorganic Chemistry, Faculty of Chemistry, Wrocław University of Technology, 50-370, Wrocław, Poland

author

Magdalena Klimek-Ochab

• Department of Bioorganic Chemistry, Faculty of Chemistry, Wrocław University of Technology, 50-370, Wrocław, Poland

author

Małgorzata Brzezińska-Rodak

• Department of Bioorganic Chemistry, Faculty of Chemistry, Wrocław University of Technology, 50-370, Wrocław, Poland

author

Ewa Żymańczyk-Duda

• Department of Bioorganic Chemistry, Faculty of Chemistry, Wrocław University of Technology, 50-370, Wrocław, Poland

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Identifiers

DOI

10.2478/s11532-013-0277-5