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2013 | 11 | 8 | 1297-1308
Article title

A simple TLC and HPTLC method for separation of selected steroid drugs

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Abstracts
EN
Chromatographic properties of five steroid drugs: cortisone, hydrocortisone, methylprednisolone, prednisolone and norgestrel have been studied by normal-, reversed-phase and hydrophilic neutral cyano-bonded silica stationary phase with five binary mobile phases (acetonitrile-water, acetonitrile-DMSO, acetonitrile-methanol, acetone-petroleum ether, acetone-water) in which the concentration of organic modifier was varied from 0 to 100% (v/v). This study reports the optimization of steroid hormones separation. Chromatographic retention data and possible retention mechanisms are discussed. Separation abilities of mobile and stationary phases were studied using the principal component analysis method. The best separation of methylprednisolone and prednisolone is with a chromatographic system included silica gel as stationary phase and mixture of acetonitrile and DMSO (10:90 v/v). These two anti-inflammatory drugs can be fast separated from norgestrel when CN is used as stationary phase and acetone and water (40:60 v/v) as mobile phase. The highest values of the parameter Δ(ΔG°) and alfa for cortisone and hydrocortisone was observed in case of using CN as stationary phase and water-acetonitryle (40:60 v/v) as mobile phase. [...]
Publisher

Journal
Year
Volume
11
Issue
8
Pages
1297-1308
Physical description
Dates
published
1 - 8 - 2013
online
1 - 6 - 2013
Contributors
  • Department of Physical Chemistry, Faculty of Pharmacy, Medical University of Gdańsk, 80-416, Gdańsk, Poland
author
  • Department of Physical Chemistry, Faculty of Pharmacy, Medical University of Gdańsk, 80-416, Gdańsk, Poland, pikul.piotr@gumed.edu.pl
  • Department of Physical Chemistry, Faculty of Pharmacy, Medical University of Gdańsk, 80-416, Gdańsk, Poland
  • Department of Economics and Law, Maritime Institute in Gdańsk, 80-830, Gdańsk, Poland
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Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.-psjd-doi-10_2478_s11532-013-0258-8
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