PL EN


Preferences help
enabled [disable] Abstract
Number of results
Journal
2013 | 11 | 5 | 706-716
Article title

Voltammetric methods of reboxetine analysis and the mechanism of its electrode reactions

Content
Title variants
Languages of publication
EN
Abstracts
EN
Reboxetine (RBX) electrochemical redox behavior at hanging mercury drop (HMDE) and glassy carbon electrodes (GCE) was studied in various pH Britton-Robinson universal buffers using cyclic voltammetry and square-wave voltammetry. RBX was reduced at the HMDE and oxidized at the GCE with reversible adsorption controlled and irreversible diffusion controlled processes respectively. The anodic peak is due to the amine and the cathodic peak may correspond to oxygen protonation. An oxidation reaction mechanism is proposed. The linear relation between peak currents and RBX concentration allowed simple, sensitive, precise and inexpensive voltammetric procedures to be developed. The limit of detection was 0.04 µM RBX. The procedures were successfully applied to human urine and RBX tablet assay. Therapeutic RBX concentrations in human serum were not detected due to strong drug-protein binding. Using bovine serum albumin, the methods were used to investigate the effect of serum protein binding on RBX determination. [...]
Keywords
Publisher
Journal
Year
Volume
11
Issue
5
Pages
706-716
Physical description
Dates
published
1 - 5 - 2013
online
27 - 2 - 2013
References
  • [1] P. Dostert, M.S. Benedetti, I. Poggesi, Neuropsychopharmacol 7, 23 (1997) http://dx.doi.org/10.1016/S0924-977X(97)00417-3[Crossref]
  • [2] L. Tanum, Acta Psychiatr. Scand. 402, 37 (2000) http://dx.doi.org/10.1034/j.1600-0447.2000.02606.x[Crossref]
  • [3] E.H.F. Wong, M.S. Sonders, S.G. Amara, P.M. Tinholt, M.F.P. Piercey, W.P. Hoffmann, D.K. Hyslop, S. Franklin, R.D. Porsolt, A. Bonsignori, N. Carfagna, R.A. McArthur, Biol Psychiatry 47, 818 (2000) http://dx.doi.org/10.1016/S0006-3223(99)00291-7[Crossref]
  • [4] S. Hartter, H. Weigmann, C. Hiemke, J. Chromatogr. B 740, 135 (2000) http://dx.doi.org/10.1016/S0378-4347(00)00040-2[Crossref]
  • [5] M.A. Raggia, R. Mandriolia, G. Casamentia, V. Volterrab, S. Pinzauti, J. Chromatogr. A 949, 23 (2002) http://dx.doi.org/10.1016/S0021-9673(01)01438-8[Crossref]
  • [6] C. Frahnert, M.L. Rao, K. Grasmader, J. Chromatogr. B 794, 35 (2003) http://dx.doi.org/10.1016/S1570-0232(03)00393-3[Crossref]
  • [7] H. Kirchherr, W.N. Kühn-Velten, J. Chromatogr. B 843, 100 (2006) http://dx.doi.org/10.1016/j.jchromb.2006.05.031[Crossref]
  • [8] N. Khalil, Talanta 80, 1251 (2010) http://dx.doi.org/10.1016/j.talanta.2009.09.010[Crossref]
  • [9] M.A. Raggi, F. Bugamelli, C. Sabbioni, A. Ferranti, S. Fanali, V. Volterra, J. Pharm. Biomed. Anal. 27, 209 (2002) http://dx.doi.org/10.1016/S0731-7085(01)00540-4[Crossref]
  • [10] F. Ghorbani-Bidkorbeh, S. Shahrokhian, A. Mohammadi, R. Dinarvand, J. Electroanal. Chem. 638, 212 (2010) http://dx.doi.org/10.1016/j.jelechem.2009.11.012[Crossref]
  • [11] C.M.A. Brett, A.M.O. Brett, Electrochemistry Principles, Methods and Applications (Oxford University Press, Oxford, 1992)
  • [12] T.H. Barri, J.A. Jönsson, Chromatographia 59, 161 (2004)
  • [13] A.M. Beltagi, O.M. Abdullah, M.M. Ghoneimc, Talanta 74, 851 (2008) http://dx.doi.org/10.1016/j.talanta.2007.07.009[Crossref]
  • [14] J. Wang, Analytical Electrochemistry, 2nd edition (Wiley-VCH, New York, 2006) http://dx.doi.org/10.1002/0471790303[Crossref]
  • [15] E.M.P.J. Garrido, J.M.P.J. Garrido, M. Esteves, A. Santos-Silva, M.P.M. Marques, F. Borges, Electroanalysis 20, 13 (2008) http://dx.doi.org/10.1002/elan.200804202[Crossref]
  • [16] P. Baumann, C. Hiemke, S. Ulrich, G. Eckermann, I. Gaertner, M. Gerlach, H.J. Kuss, G. Laux, B. Müller-Oerlinghausen, M.L. Rao, P. Riederer, G. Zernig, Pharmacopsychiatry 37, 243 (2004) http://dx.doi.org/10.1055/s-2004-832687[Crossref]
  • [17] G. Laux, P. Baumann, C. Hiemke, J. Neural. Transm. 72, 261 (2007) http://dx.doi.org/10.1007/978-3-211-73574-9_32[Crossref]
  • [18] N.G. Kadhe, A.J. Chillar, Y.A. Deshmukh, J. Postgradu. Med. 49, 373 (2003)
  • [19] S. Bi, L. Yan, B. Wang, J. Bian, Y. Sun, J. Lumin. 131, 866 (2011) http://dx.doi.org/10.1016/j.jlumin.2010.12.016[Crossref]
  • [20] H.H. Cai, X. Zhong, P.H. Yang, W. Wei, J. Chen, J. Cai, Colloids Surf. A 372, 35 (2010) http://dx.doi.org/10.1016/j.colsurfa.2010.09.017[Crossref]
  • [21] C.J. Collins, C. Lyons, J. Strutwolf, D.W.M. Arrigan, Talanta 80, 1993 (2010) http://dx.doi.org/10.1016/j.talanta.2009.10.060[Crossref]
  • [22] L. Fotouhi, S. Banafsheh, M.M. Heravi, Bioelectrochem. 77, 26 (2009) http://dx.doi.org/10.1016/j.bioelechem.2009.05.011[Crossref]
  • [23] Q.H. Wei, L.J. Han, J.H. Chen, F.N. Xiao, S. L. Zeng, G.N. Chen, Chin. Chem. Lett. 22, 713 (2011) http://dx.doi.org/10.1016/j.cclet.2010.12.040[Crossref]
Document Type
Publication order reference
YADDA identifier
bwmeta1.element.-psjd-doi-10_2478_s11532-013-0213-8
Identifiers
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.