Comprehensive evaluation of biogenic amines and related drugs’ antiradical activity using reactive 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical

• Authors: Costel Sârbu , Dorina Casoni
• Languages of publication: EN

Abstracts

EN

A comprehensive study of biogenic amines and related drugs as free radical scavengers and potential antioxidants was carried out using the stable free radical 2,2-diphenyl-1-picrylhydrazyl (DPPH·). The results of the effect of test duration and the relative concentration on the ability of the compounds to scavenge the DPPH· were investigated and discussed. The antiradical activity of amines was compared with the activity of some reference antioxidants (phenols, phenolic acids, flavonols and other antioxidants). Some particular insights related to the mechanism of reactivity toward the DPPH· were investigated by carrying out kinetic studies in methanol for different relative concentrations. According to the obtained results, catecholamines and especially their related drugs (D-dopa, adrenalone, S-(−)-carbidopa and isoprenaline) showed a fast reactivity towards DPPH· and the highest antiradical activity which increased in a concentration-dependent manner. Moreover, catecholamines proved to be more powerful scavengers than ascorbic and caffeic acids even at low concentrations while their related drugs (D-dopa, adrenalone and S-(−)-carbidopa) showed higher antiradical activity than gallic acid for all of the investigated concentrations. [...]

Keywords

EN

Biogenic amines; Related drugs; Reference antioxidants; DPPH; Antiradical activity

• Publisher: De Gruyter Open
• Journal: Open Chemistry
• Year: 2013
• Volume: 11
• Issue: 5
• Pages: 679-688

Dates

published

1 - 5 - 2013

online

27 - 2 - 2013

Contributors

author

Costel Sârbu

• Faculty of Chemistry and Chemical Engineering, Babeş-Bolyai University, RO-400028, Cluj-Napoca, România

author

Dorina Casoni

• Faculty of Chemistry and Chemical Engineering, Babeş-Bolyai University, RO-400028, Cluj-Napoca, România

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Identifiers

DOI

10.2478/s11532-013-0210-y