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Journal
2012 | 10 | 6 | 1791-1798
Article title

Spatial relationships between the pharmacophores of endomorphin-2: a comparative study of stereoisomers

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Content
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Languages of publication
EN
Abstracts
EN
The spatial relationships between the pharmacophore elements were investigated in the case of four different stereoisomeric forms of opioid tetrapeptide, endomorphin-2, taking into account the L-D and cis-trans isomerisms. On the basis of distances and angles measured between the pharmacophoric points, a comparative analysis of conformational distributions was performed, applying a variety of distance-angle maps. The results obtained by this theoretical study indicated that the stereoisomers of endomorphin-2 could be distinguished from one another, based on the comparative analysis of distance-angle maps. Nevertheless, it could be concluded that this method proved to be suitable to examine the effects of L-D and cis-trans isomerisms on the spatial relationships of the pharmacophores of tetrapeptide. [...]
Publisher

Journal
Year
Volume
10
Issue
6
Pages
1791-1798
Physical description
Dates
published
1 - 12 - 2012
online
21 - 9 - 2012
Contributors
  • Institute of Biophysics, Biological Research Centre, Hungarian Academy of Sciences, H-6726, Szeged, Hungary, leitgeb@brc.hu
References
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Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.-psjd-doi-10_2478_s11532-012-0105-3
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