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2012 | 10 | 6 | 1808-1816
Article title

Simultaneous analysis of first-line anti-tuberculosis drugs in tablets by UV spectrophotometry compared to capillary zone electrophoresis

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EN
Abstracts
EN
The development and optimization of a novel UV spectrophotometric methodology was proposed for simultaneous analysis of ethambutol (ETB), isoniazid (ISO), rifampicin (RIF) and pyrazinamide (PYR), using multivariate calibration based on the partial least squares method (PLS). The methodology was successfully applied for analysis of four-drug fixed dose combination (4-FDC) tablets used for tuberculosis treatment. A 34 Box-Behnken design, with triplicate in central point, was used for sample preparation in the calibration step. In the present case, nine latent variables were chosen for the model development that presented the smallest RMSECV and explain 98.76% of data variance in Y block (concentrations of ETB ISO, RIF and PYR) and 99.93% of data variance in X block (spectral data). PLS models for ETB, ISO, RIF and PYR presented RMSEP and R2 values of 0.23 mg L−1 and 0.971; 0.14 mg L−1 and 0.731; 0.11 mg L−1 and 0.990 and 0.57 mg L−1 and 0.972, respectively. A validation step was performed based on the comparison between the UV spectrophotometric proposed methodology and capillary zone electrophoresis (CZE) in 4-FDC real samples and no significant difference was found between two methodologies at 95% of confidence level. [...]
Publisher

Journal
Year
Volume
10
Issue
6
Pages
1808-1816
Physical description
Dates
published
1 - 12 - 2012
online
21 - 9 - 2012
Contributors
  • Department of Chemistry — ICE, Federal University of Juiz de Fora, CEP 36036-330, Juiz de Fora — MG, Brazil
author
  • Department of Chemistry — ICE, Federal University of Juiz de Fora, CEP 36036-330, Juiz de Fora — MG, Brazil
author
  • Institute of Technology in Pharmaceuticals — Farmanguinhos, Oswaldo Cruz Foundation, CEP 21041-250, Rio de Janeiro — RJ, Brazil
  • Institute of Chemistry, State University of Campinas, CEP 13084-971, Campinas — SP, Brazil
  • Institute of Chemistry, State University of Campinas, CEP 13084-971, Campinas — SP, Brazil
author
  • Institute of Chemistry, State University of Campinas, CEP 13084-971, Campinas — SP, Brazil
  • Department of Chemistry — ICE, Federal University of Juiz de Fora, CEP 36036-330, Juiz de Fora — MG, Brazil, marcone.oliveira@ufjf.edu.br
References
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Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.-psjd-doi-10_2478_s11532-012-0102-6
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