Isocratic liquid chromatographic determination of three paraben preservatives in hygiene wipes using a reversed phase core-shell narrow-bore column

• Authors: Paraskevas Tzanavaras , Theano Karakosta , Pantelis Rigas , Demetrius Themelis , Anastasia Zotou
• Languages of publication: EN

Abstracts

EN

The first HPLC method for the separation of three paraben preservatives (methyl-, ethyl- and propyl parabens) using a core-shell analytical column is reported in this study. The separation was completed in less than 8 min at a low flow rate of 0.4 mL min−1 and an isocratic mobile phase containing 20% acetonitrile as organic modifier. The backpressure was HPLC equipment. The proposed analytical procedure was validated for linearity (0.5–20 µg L−1), limits of detection (15–43 µg L−1) and quantification (50–142 µg L−1), selectivity, within day (1.3–1.5%) and day-to-day (3.4–4.6%) precision and accuracy. The proposed method has been applied to the determination of the selected paraben preservatives in commercially available hygiene wipes. The mean percent recoveries were found to be in the range of 98.0–98.4%. [...]

Keywords

EN

High-performance liquid chromatography; Core-shell (or fused core) column; Parabens; Hygiene wipes

• Publisher: De Gruyter Open
• Journal: Open Chemistry
• Year: 2012
• Volume: 10
• Issue: 5
• Pages: 1459-1463

Dates

published

1 - 10 - 2012

online

21 - 7 - 2012

Contributors

author

Paraskevas Tzanavaras

• Laboratory of Analytical Chemistry, Department of Chemistry, Aristotelian University of Thessaloniki, GR-54124, Thessaloniki, Greece

author

Theano Karakosta

• Laboratory of Analytical Chemistry, Department of Chemistry, Aristotelian University of Thessaloniki, GR-54124, Thessaloniki, Greece

author

Pantelis Rigas

• Department of Fisheries and Aquaculture Technology, Alexander Technological Educational Institute of Thessaloniki, GR-63200, N. Moudania, Greece

author

Demetrius Themelis

• Laboratory of Analytical Chemistry, Department of Chemistry, Aristotelian University of Thessaloniki, GR-54124, Thessaloniki, Greece

author

Anastasia Zotou

• Laboratory of Analytical Chemistry, Department of Chemistry, Aristotelian University of Thessaloniki, GR-54124, Thessaloniki, Greece

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Identifiers

DOI

10.2478/s11532-012-0091-5