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2012 | 10 | 5 | 1500-1505

Article title

Comparison of structure, logP and P388 cytotoxicity of some phenyl and ferrocenyl cyclic chalcone analogues. Application of RP-TLC for logP determination of the ferrocenyl analogues


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Cyclic chalcone analogues (2–5) and their ferrocenyl counterparts (6–10) were synthesized and their logP and P388 cyctotoxity were investigated. The structures of the newly synthesized compounds were confirmed by IR 1H and 13NMR spectroscopy. Comparison of conjugation and stereochemistry of the respective derivatives showed similar characteristics compared to ones with some higher degree of conjugation in the ferrocenyl series. Comparison of logP of the ferrocenyl derivatives determined by a validated RP-TLC method showed the ferrocenyl derivatives to have higher logP TLC. The results demonstrate that the differences in three dimensional shape, conjugation and lipophilicity do not have strong influence on the P388 cytotoxicity of the investigated phenyl (1−5) and ferrocenyl (6−10) enones. [...]










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1 - 10 - 2012
21 - 7 - 2012


  • Institute of Pharmaceutical Chemistry, University of Pécs, Pécs, 7634, Hungary
  • Institute of Pharmaceutical Chemistry, Semmelweis University, Budapest, 1092, Hungary
  • Institute of Pharmaceutical Chemistry, University of Pécs, Pécs, 7634, Hungary
  • Department of Chemistry, Eötvös Lóránd University (ELTE), and Protein Modelling Group ELTE-HAS, Budapest, 1117, Hungary
  • Department of Chemistry, California State University Hayward, Hayward, CA, 94542, USA
  • Department of Pharmacology, University of Alberta, Edmonton, AB, T6G 2H7, Canada


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