Journal
Article title
Title variants
Languages of publication
Abstracts
Injectable solutions used in treatment of intense pain are based on combinations of active ingredients such as metamizole sodium (MTZ), pitofenone hydrochloride (PTF) and fenpiverine bromide (FPB). The simultaneous chromatographic assay of such combinations poses difficulties due to their structural variety, highly polar character, and wide concentration ranges (500 mg mL−1 for MTZ, 2 mg mL−1 for PTF and 0.02 mg mL−1 for FPB). Fast hydrolysis of MTZ on aqueous dilution causes additional problems due to impurity (MTC) formation. Sodium hexane sulphonate (10 mM) was used as ion pairing agent for PTF, FPB and MTC in a mobile phase consisting of 48/52 (v/v) methanol and aqueous 0.2% triethylamine at pH=3. The ionic liquid 1-butyl-1-methyl-pyrrolidinium tetrafluoroborate (10 mM) was used as mobile phase additive to preserve the MTZ peak symmetry. The minor active ingredient FPB was selectively extracted into 1-octanol by ion pair formation with picric acid. A 20 µL aliquot of the organic layer was directly injected into the column. [...]
Journal
Year
Volume
Issue
Pages
1360-1368
Physical description
Dates
published
1 - 8 - 2012
online
29 - 5 - 2012
Contributors
author
- Faculty of Chemistry, Department of Analytical Chemistry, University of Bucharest, Bucharest, 50663, Romania
author
- Faculty of Chemistry, Department of Analytical Chemistry, University of Bucharest, Bucharest, 50663, Romania
author
- Faculty of Chemistry, Department of Analytical Chemistry, University of Bucharest, Bucharest, 50663, Romania
author
- Faculty of Chemistry, Department of Analytical Chemistry, University of Bucharest, Bucharest, 50663, Romania, avmedved@yahoo.com
References
- [1] A. Berthod, M. Ruiz-Angel, S. Carda-Broch, J. Chromatogr. A 1184, 6 (2008) http://dx.doi.org/10.1016/j.chroma.2007.11.109[Crossref]
- [2] D. Han, K.H. Row, Molecules 15, 2405 (2010) http://dx.doi.org/10.3390/molecules15042405[Crossref]
- [3] L.H. Marcolino-Junior, R.A. Sousa, O. Fatibello-Filho, F.C. Moraes, M. Teixeira, Anal. Lett. 14, 2315 (2005) http://dx.doi.org/10.1080/15265160500316351[Crossref]
- [4] Q. Xiang, G. Niu, X. Wu, G. Chen, Chem. Res. Chin. Univ. 6, 654 (2007) http://dx.doi.org/10.1016/S1005-9040(07)60142-1[Crossref]
- [5] N. Erk, F. Onur, Anal. Lett. 30, 1201 (1997) http://dx.doi.org/10.1080/00032719708004049[Crossref]
- [6] H.N. Dogan, Pharmazie 51, 773 (1996)
- [7] T. Aburjai, B.I. Amro, K. Aiedeh, M. Abuirjeie, S. Al-Khalil, Pharmazie 55, 751 (2000)
- [8] B. Morelli, Anal. Lett. 31, 2431 (1998) http://dx.doi.org/10.1080/00032719808005316[Crossref]
- [9] Y. Huang, C. Zhang, X. Zhang, Z. Zhang, Anal. Lett. 32, 933 (1999) http://dx.doi.org/10.1080/00032719908542867[Crossref]
- [10] H.Z. Senyuva, I. Aksahin, S. Ozcan, B.V. Kabasakal, Anal. Chim. Acta 547, 73 (2005) http://dx.doi.org/10.1016/j.aca.2004.12.053[Crossref]
- [11] A. Salmeron-Garcia, N. Navas, A. Martin, E. Roman, J. Cabeza, L.F. Capitan-Vallvey, J. Chrom. Sci. 3, 231 (2009) [Crossref]
- [12] L.G. Tillman, G.E. Hardee, Anal. Lett. 15, 1897 (1985) http://dx.doi.org/10.1080/00032718508062915[Crossref]
- [13] B. Morelli, J. Pharm. Biomed. Anal. 3, 423 (2003) http://dx.doi.org/10.1016/S0731-7085(03)00290-5[Crossref]
- [14] V. Kubicek, D. Kucova, P. Cisar, V. Buresova, Microchim. Acta 142, 273 (2003) http://dx.doi.org/10.1007/s00604-003-0031-3[Crossref]
- [15] D. Radulovic, L. Zivarovic, D. Zivanov-Stakic, Acta Pol. Pharm. 46, 506 (1989)
- [16] ChemAxon Software: Marvin with calculator plugins, version 5.4.0.0 (ChemAxon, Hungary, 2010)
- [17] M.P. Marszall, R. Kaliszan, Critical Rev. Anal. Chem. 37, 127 (2007) http://dx.doi.org/10.1080/10408340601107847[Crossref]
- [18] Y. Wang, M. Tian, W. Bi, K.H. Row, Int. J. Mol. Sci. 10, 2591 (2009) http://dx.doi.org/10.3390/ijms10062591[Crossref]
- [19] L. He, W. Zhang, L. Zhao, X. Liu, S. Jiang, J. Chromatogr. A 1007, 39 (2003) http://dx.doi.org/10.1016/S0021-9673(03)00987-7[Crossref]
- [20] S. Udrescu, A. Medvedovici, V. David, J. Sep. Sci. 31, 2939 (2008) http://dx.doi.org/10.1002/jssc.200800299[Crossref]
- [21] A. Medvedovici, V. David, V. David, C. Georgita, J. Liq. Chrom. & Rel. Technol. 30, 199 (2007) http://dx.doi.org/10.1080/10826070601064201[Crossref]
- [22] S. Udrescu, I. Sora, F. Albu, V. David, A. Medvedovici, J. Pharm. Biomed. Anal. 54, 1163 (2011) http://dx.doi.org/10.1016/j.jpba.2010.12.005[Crossref]
- [23] A. Medvedovici, S. Udrescu, F. Albu, F. Tache, V. David, Bioanalysis 3, 1935 (2011) http://dx.doi.org/10.4155/bio.11.148[Crossref]
- [24] S. Keunchkarian, M. Reta, L. Romero, C. Castells, J. Chromatogr. A 1119, 20 (2006) http://dx.doi.org/10.1016/j.chroma.2006.02.006[Crossref]
- [25] E. Loeser, P. Drumm, J. Sep. Sci. 29, 2487 (2006) http://dx.doi.org/10.1002/jssc.200600299[Crossref]
- [26] E. Loeser, S. Babiak, P. Drumm, J. Chromatogr. A 1216, 3409 (2009) http://dx.doi.org/10.1016/j.chroma.2009.02.012[Crossref]
- [27] Q2B Validation of Analytical Procedures: Methodology (Center for Drug Evaluation and Research, ICH, 1996)
Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.-psjd-doi-10_2478_s11532-012-0059-5