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2012 | 10 | 4 | 1360-1368
Article title

Use of an immiscible diluent in ionic liquid / ion pair LC for the assay of an injectable analgesic

Content
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Languages of publication
EN
Abstracts
EN
Injectable solutions used in treatment of intense pain are based on combinations of active ingredients such as metamizole sodium (MTZ), pitofenone hydrochloride (PTF) and fenpiverine bromide (FPB). The simultaneous chromatographic assay of such combinations poses difficulties due to their structural variety, highly polar character, and wide concentration ranges (500 mg mL−1 for MTZ, 2 mg mL−1 for PTF and 0.02 mg mL−1 for FPB). Fast hydrolysis of MTZ on aqueous dilution causes additional problems due to impurity (MTC) formation. Sodium hexane sulphonate (10 mM) was used as ion pairing agent for PTF, FPB and MTC in a mobile phase consisting of 48/52 (v/v) methanol and aqueous 0.2% triethylamine at pH=3. The ionic liquid 1-butyl-1-methyl-pyrrolidinium tetrafluoroborate (10 mM) was used as mobile phase additive to preserve the MTZ peak symmetry. The minor active ingredient FPB was selectively extracted into 1-octanol by ion pair formation with picric acid. A 20 µL aliquot of the organic layer was directly injected into the column. [...]
Publisher

Journal
Year
Volume
10
Issue
4
Pages
1360-1368
Physical description
Dates
published
1 - 8 - 2012
online
29 - 5 - 2012
Contributors
author
  • Faculty of Chemistry, Department of Analytical Chemistry, University of Bucharest, Bucharest, 50663, Romania
  • Faculty of Chemistry, Department of Analytical Chemistry, University of Bucharest, Bucharest, 50663, Romania
author
  • Faculty of Chemistry, Department of Analytical Chemistry, University of Bucharest, Bucharest, 50663, Romania
  • Faculty of Chemistry, Department of Analytical Chemistry, University of Bucharest, Bucharest, 50663, Romania, avmedved@yahoo.com
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Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.-psjd-doi-10_2478_s11532-012-0059-5
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