The interaction of [Pd(N,N-dimethylaminopropylamine)(H2O)]2+ with dicarboxylic acids and inosine: Thermodynamic model for carboplatin drug

• Authors: Mohamed Shehate , Mohamed Shoukry , Mona Ragab
• Languages of publication: EN

Abstracts

EN

The Pd(DMPA)Cl2 complex, where DMPA = N,N-dimethylaminoproylamine, was synthesized and characterized. The stoichiometry and stability constants of the complexes formed between various dicarboxylic acids and [Pd(DMPA)(H2O)2]2+ were investigated. The effect of solvent dielectric constant, chloride ion concentration of the medium and temperature on the stability constant of the cyclobutanedicaroxylic acid (CBDCA) complex was investigated. The equilibrium constants for the displacement of coordinated CBDCA by inosine, taken as an example of DNA constituents, were calculated. The results are expected to contribute to the chemistry of antitumour agents. [...]

Keywords

EN

N,N-dimethylaminopropylamine; Cylcobutanedicarboxylic acid; DNA; Displacement reaction; Stability constant

• Publisher: De Gruyter Open
• Journal: Open Chemistry
• Year: 2012
• Volume: 10
• Issue: 4
• Pages: 1253-1261

Dates

published

1 - 8 - 2012

online

29 - 5 - 2012

Contributors

author

Mohamed Shehate

• Department of Chemistry, Faculty of Science, University of Cairo, 12613, Giza, Egypt

author

Mohamed Shoukry

• Department of Chemistry, Faculty of Science, University of Cairo, 12613, Giza, Egypt

author

Mona Ragab

• Department of Chemistry, Faculty of Science, University of Cairo, 12613, Giza, Egypt

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Identifiers

DOI

10.2478/s11532-012-0053-y