The interaction of [Pd(N,N-dimethylaminopropylamine)(H2O)]2+ with dicarboxylic acids and inosine: Thermodynamic model for carboplatin drug

• Authors: Mohamed Shehate , Mohamed Shoukry , Mona Ragab
• Languages of publication: EN

Abstracts

EN

The Pd(DMPA)Cl2 complex, where DMPA = N,N-dimethylaminoproylamine, was synthesized and characterized. The stoichiometry and stability constants of the complexes formed between various dicarboxylic acids and [Pd(DMPA)(H2O)2]2+ were investigated. The effect of solvent dielectric constant, chloride ion concentration of the medium and temperature on the stability constant of the cyclobutanedicaroxylic acid (CBDCA) complex was investigated. The equilibrium constants for the displacement of coordinated CBDCA by inosine, taken as an example of DNA constituents, were calculated. The results are expected to contribute to the chemistry of antitumour agents. [...]

Keywords

EN

N,N-dimethylaminopropylamine   Cylcobutanedicarboxylic acid   DNA   Displacement reaction   Stability constant  

• Publisher: De Gruyter Open
• Journal: Open Chemistry
• Year: 2012
• Volume: 10
• Issue: 4
• Pages: 1253-1261

Dates

published

1 - 8 - 2012

online

29 - 5 - 2012

References

• [1] R. Lippert (Ed.), Cisplatin: Chemistry and Biochemistry of A leading Anticancer Drug (Wiley-VCH, Weinhm, 1999) http://dx.doi.org/10.1002/9783906390420[Crossref]
• [2] E. Wong, C.M. Giandomenico, Chem. Rev. 99, 2451 (1999) http://dx.doi.org/10.1021/cr980420v[Crossref]
• [3] L. Kelland, Nat. Rev., Cancer 7, 573 (2007) http://dx.doi.org/10.1038/nrc2167[Crossref]
• [4] N.J. Wheate, J.G. Collins, Coord. Chem. Rev. 241, 133 (2003) http://dx.doi.org/10.1016/S0010-8545(03)00050-X[Crossref]
• [5] N.J. Wheate, J.G. Collins, Curr. Med. Chem.-Anti-Cancer Agents 5, 267 (2005) http://dx.doi.org/10.2174/1568011053765994[Crossref]
• [6] N.D. Tinker, H.L. Sharma, C.A. Mc Auliffe, In: M. Nicolini (Ed.), Platinum and other metal Coordination Compounds in Cancer Chemotherapy (Martinus Nijhoff Publ., Boston, MA, 1988) 144 http://dx.doi.org/10.1007/978-1-4613-1717-3_18[Crossref]
• [7] L. Canovese, L. Catalini, G. Chessa, M.L. Tobe, J. Chem. Soc. Dalton Trans. 2135 (1988). [Crossref]
• [8] A. Shoukry, T. Rau, M. Shoukry, R. van Eldik, J. Chem. Soc. Dalton Trans. 3105 (1988)
• [9] B. Petrovic, Z.D. Bugarcic, R. van Eldik, Dalton Trans. 807 ( 2008)
• [10] N. Summa, T. Soldatovic, L. Dahlenburg, Z.D. Bugarcic, R. van Eldik, J. Biol. Inorg. Chem. 461 (2007) [Crossref]
• [11] T. Soldatovic, M.M. Shoukry, R. Puchta, Z.D. Bugarcic, R. van Eldik, Eur. J. Inorg. Chem. 2261 (2009)
• [12] M.R. Shehata, M.M. Shoukry, F.H. Abdel-Shakour, R. van Eldik, Eur. J. Inorg. Chem. 3912 (2009)
• [13] M.R. Shehata, M.M. Shoukry, F.M. Nasr, R. van Eldik, Dalton Trans. 779 (2008)
• [14] A.A. El-Sherif, M.M. Shoukry, R. van Eldik, J. Chem. Soc. Dalton Trans. 1425 (2003) [Crossref]
• [15] Z.D. Bugarcic, M.M. Shoukry, R. van Eldik, J. Chem. Soc. Dalton Trans. 3945 (2002) [Crossref]
• [16] Z.D. Bugarcic, D.M. Jancic, A.A. Shoukry, M.M. Shoukry, Monatsh. Fur Chem. 135, 151 (2004)
• [17] A.T.M. Marcelis, H.J. Korte, B. Krebs, J. Reedijk, Inorg. Chem. 21, 4059 (1982) http://dx.doi.org/10.1021/ic00141a036[Crossref]
• [18] R.E. Cramer, P.L. Dahlstrom, Inorg. Chem. 24, 3420 (1985) http://dx.doi.org/10.1021/ic00215a025[Crossref]
• [19] L.G. Marzilli, F.P. Intini, D. Kiser, H.C. Wong, S.O. Ano, P.A. Marzilli, G. Natile, Inorg. Chem. 37, 6898 (1998) http://dx.doi.org/10.1021/ic980843f[Crossref]
• [20] T. Rau, M.M. Shoukry, R. van Eldik, Inorg. Chem. 36, 1454 (1997) http://dx.doi.org/10.1021/ic961192v[Crossref]
• [21] R.G. Bates, Determination of pH: Theory and Practice, 2nd edition (Wiley Interscience, New York, 1975)
• [22] M.M. Shoukry, W.M. Hosny, M.M. Khalil, Transition Met. Chem. 20, 252 (1995) http://dx.doi.org/10.1007/BF00143487[Crossref]
• [23] P. Gans, A. Sabarini, A. Vacca, Inorg. Chim. Acta, 18, 237 (1976) http://dx.doi.org/10.1016/S0020-1693(00)95610-X[Crossref]
• [24] D.D. Perrin, Stability Constants of Metal Ion Complexes: Part B, Organic Ligands (Pergamon Press, Oxford, 1979)
• [25] U. Kramer-Schnabel, P.W. Linder, Inorg. Chem. 30, 1248 (1991) http://dx.doi.org/10.1021/ic00006a017[Crossref]
• [26] D.C. Rees, J. Mol. Biol. 141, 323 (1980) http://dx.doi.org/10.1016/0022-2836(80)90184-9[Crossref]
• [27] N.K. Rogers, G.R. Moore, M.J.E. Sternberg, J. Mol. Biol. 182, 613 (1985) http://dx.doi.org/10.1016/0022-2836(85)90248-7[Crossref]
• [28] G. Akerlof, O.A. Short, J. Am. Chem. Soc. 75, 6357 (1953)
• [29] E.R. Jamieson, S.J. Lipperd, Chem. Rev. 92, 2467 (1999) http://dx.doi.org/10.1021/cr980421n[Crossref]
• [30] B.P. Esposito, R. Najjar, Coord. Chem. Rev. 232, 137 (2002) http://dx.doi.org/10.1016/S0010-8545(02)00049-8[Crossref]
• [31] M.R. Shehata, M.M. Shoukry, A.A. Osman, A.T. Abdel Karim, Spectochim. Acta Part A 79, 1226 (2011) http://dx.doi.org/10.1016/j.saa.2011.04.047[Crossref]
• [32] M.R. Shehata, M.M. Shoukry, S. Ali, Spectochim. Acta Part A 91, 383 (2012) http://dx.doi.org/10.1016/j.saa.2012.01.039[Crossref]
• [33] B. Lippert, Cisplatin: Chemistry and biochemistry of a leading anticancer drug (Wiley-VCH, Zurich, 1999) http://dx.doi.org/10.1002/9783906390420[Crossref]

Identifiers

DOI

10.2478/s11532-012-0053-y