Synthesis and biological activity of novel heavy metal complexes of 5-amino-1, 10-phenanthroline and 1,10-phenanthroline

• Authors: Nikolay Kaloyanov , Mihail Neykov , Diana Wesselinova , Georgi Dimitrov
• Languages of publication: EN

Abstracts

EN

Novel heavy metal complexes: Sr(5-NH2-phen)4(NO3)(OH)(H2O)2 (1) (synthesized via a static self-assembly process) and Sn(phen)(NO3)(OH)(H2O) (2), Sn(5-NH2-phen)(OH)(Cl)(H2O) (3), Pb(5-NH2-phen)(NO3)2(H2O) (4) (obtained via metal competitive reactions under mild conditions) were reported. The coordination compounds were characterized by elemental analysis, FTIR-spectroscopy and FAB-mass spectrometry. Their cytotoxicity was measured by MTS-test towards human tumour (MDA-MB-231, HT-29, HeLa, HepG2) and non-tumour diploid (Lep-3) cell lines. The most pronounced cytotoxic effect on all cancer lines showed 1 and 4 at their high concentrations as well as 1 at its lower ones (≤ 4×10−2 mg). Therefore, strontium complex of 5-amino-o-phenanthroline (1) exhibited the widest antitumour spectrum activity, having no toxicity to non-tumour cells at quantities ≤ 4×10−2 mg. The computed EC50 values of 1–4 against MDA-MB-231, HT-29, HeLa, HepG2 varied from 1.40×10−3 to 6.31×10−6 M. Towards Lep-3 substances 2–4 showed IC50 7.52×10−4 − 0.44 M. Substance 1 possess EC50=1.26×10−7 M to the non-tumour cells. [...]

Keywords

EN

Metal complexes; Self-assembly; 5-amino-1,10-phenanthroline; 1,10-phenanthroline; Cytotoxic activity

• Publisher: De Gruyter Open
• Journal: Open Chemistry
• Year: 2012
• Volume: 10
• Issue: 4
• Pages: 1034-1041

Dates

published

1 - 8 - 2012

online

29 - 5 - 2012

Contributors

author

Nikolay Kaloyanov

• Department of Organic Chemistry, University of Chemical Technology and Metallurgy, Sofia, 1756, Bulgaria

author

Mihail Neykov

• Department of Organic Chemistry, University of Chemical Technology and Metallurgy, Sofia, 1756, Bulgaria

author

Diana Wesselinova

• Institute of Experimental Morphology, Pathology and Anthropology with Muzeum, Bulgarian Academy of Sciences, Sofia, 1113, Bulgaria

author

Georgi Dimitrov

• Department of Organic Chemistry, University of Chemical Technology and Metallurgy, Sofia, 1756, Bulgaria

References

• [1] G.F. Swiegers, T.J. Malefetse, Chem. Rev. 100, 3483 (2000) http://dx.doi.org/10.1021/cr990110s[Crossref]
• [2] S. Leininger, B. Olenyuk, P.J. Stang, Chem. Rev. 100, 853 (2000) http://dx.doi.org/10.1021/cr9601324[Crossref]
• [3] V. G. Kumar Das, Y. Chee-Keong, P.J. Smith, J. Organometallic Chem. 327, 311 (1987) http://dx.doi.org/10.1016/S0022-328X(00)99748-1[Crossref]
• [4] S. Saha, A. K. Sengupta, J. Fluorine Chem. 62, 1 (1993) http://dx.doi.org/10.1016/S0022-1139(00)80074-3[Crossref]
• [5] S.V. Larionov, R.F. Klevtsova, E.A. Sankova, L.A. Glinskaya, T.E. Kokina, Russ. J. Inorg. Chem. 53, 1417 (2008) http://dx.doi.org/10.1134/S003602360809012X[Crossref]
• [6] W. Wang, S. Chen, Sh. Gao, Eur. J. Inorg. Chem. 2009, 3475 (2009) http://dx.doi.org/10.1002/ejic.200900335[Crossref]
• [7] R.T. Gephart, N.J. Williams, J.H. Reibenspies, A.S. De Sousa, R.D. Hancock, Inorg. Chem. 47, 10342 (2008) http://dx.doi.org/10.1021/ic8008656[Crossref]
• [8] G.D. Dimitrov, M.S. Atanassova, Z. Anorg. Allg. Chem. 629, 12 (2003) http://dx.doi.org/10.1002/zaac.200390005[Crossref]
• [9] M. Neykov, T.V. Almsick, G.D. Dimitrov, Z. Anorg. Allg. Chem. 632, 1554 (2006) http://dx.doi.org/10.1002/zaac.200500534[Crossref]
• [10] M.S. Atanassova, G.D. Dimitrov, J. Univ. Chem. Technol. Metallurgy, Sofia, 37, 85 (2002)
• [11] G.D. Dimitrov, N. Kaloyanov, P. Petrov, D. Wesselinova, Compt. Rend. l’Acad. bulg. Sci. 61, 595 (2008)
• [12] D. Wesselinova, M. Neykov, N. Kaloyanov, R. Toshkova, G.D. Dimitrov, Eur. J. Med. Chem. 44, 2720 (2009) http://dx.doi.org/10.1016/j.ejmech.2009.01.036[Crossref]
• [13] D. Wesselinova, N. Kaloyanov, G.D. Dimitrov, Eur. J. Med. Chem. 44, 5099 (2009) http://dx.doi.org/10.1016/j.ejmech.2009.07.016[Crossref]
• [14] N. Kaloyanov, R. Alexandrova, D.W. Wesselinova, H. Mayer-Figge, W.S. Sheldrick, G.D. Dimitrov, Eur. J. Med. Chem. 46, 1992 (2011) http://dx.doi.org/10.1016/j.ejmech.2011.02.018[Crossref]
• [15] E.J. Gao, Q.T. Liu, Acta Chim. Sinica 60, 674 (2002)
• [16] E.J. Gao, Q.T. Liu, L.Y. Duan, Russ. J. Coord. Chem. 33, 120 (2007) http://dx.doi.org/10.1134/S107032840702008X[Crossref]
• [17] R.K. Narla, Y. Dong, O.J. D’Cruz, C. Navara, F.M. Uckun, Clin. Cancer Res. 6, 1546 (2000)
• [18] CellTiter 96 Non-Radioactive Cell proliferation assay, Technical Bulletin #TB112 (Promega Corporation, USA, December 1999)
• [19] M.V. Berridge, A.S. Tan, Arch. Biochem. Biophys. 303, 474 (1993) http://dx.doi.org/10.1006/abbi.1993.1311[Crossref]

Identifiers

DOI

10.2478/s11532-012-0046-x