Bioanalysis of small-molecule drugs in nasal and paranasal tissues and secretions: Current status and perspectives

• Authors: Ana Serralheiro , Gilberto Alves , Amílcar Falcão
• Languages of publication: EN

Abstracts

EN

Over the last years, interest in intranasal administration as an alternative and promising route for the delivery of drugs withlocal, systemic, and even central nervous system action has tremendously increased. Accordingly, understanding of the propertiesand characteristics of the nasal cavity as well as the biodisposition processes of drugs into the nasal compartments is acquiringa significant prominence in the field of pharmacology. In this context, the development and validation of bioanalytical methodologies for the quantitative measurement of drugs and their metabolites in nasal and paranasal tissues and/or secretions is of the utmostimportance. However, currently, information concerning bioanalysis of drugs in nasal and paranasal tissues and/or secretionsis scattered. This review aims to provide a valuable overview of the methodologies that have been used for the collectionand preparation of nasal and paranasal samples with special emphasis placed on the review of liquid chromatographic methodsemployed for the quantitative determination of small-molecule drugs and their metabolites in such specimens. [...]

Keywords

EN

Nasal and paranasal tissues and secretions; Bioanalysis; Liquid chromatographic methods

• Publisher: De Gruyter Open
• Journal: Open Chemistry
• Year: 2012
• Volume: 10
• Issue: 3
• Pages: 686-702

Dates

published

1 - 6 - 2012

online

23 - 3 - 2012

Contributors

author

Ana Serralheiro

author

Gilberto Alves

author

Amílcar Falcão

References

• [1] N.M. Veldhorst-Janssen, A.A. Fiddelers, P.H. van der Kuy, C. Neef, M.A. Marcus, Clin. Ther. 31, 2954 (2009) http://dx.doi.org/10.1016/j.clinthera.2009.12.015[Crossref]
• [2] D.P. Wermeling, Neurotherapeutics 6, 352 (2009) http://dx.doi.org/10.1016/j.nurt.2009.01.002[Crossref]
• [3] A. Pires, A. Fortuna, G. Alves, A. Falcão, J. Pharm. Pharm. Sci. 12, 288 (2009)
• [4] J.P. Wong et al., Expert Rev. Respir. Med. 4, 171 (2010) http://dx.doi.org/10.1586/ers.10.15[Crossref]
• [5] C. Bitter, K. Suter-Zimmermann, C. Surber, Curr. Probl. Dermatol. 40, 20 (2011) http://dx.doi.org/10.1159/000321044[Crossref]
• [6] L. Illum, J. Control. Release 87, 187 (2003) http://dx.doi.org/10.1016/S0168-3659(02)00363-2[Crossref]
• [7] H.R. Costantino, L. Illum, G. Brandt, P.H. Johnson, S.C. Quay, Int. J. Pharm. 337, 1 (2007) http://dx.doi.org/10.1016/j.ijpharm.2007.03.025[Crossref]
• [8] R.J. Harvey, R.J. Schlosser, Otolaryngol. Clin. North Am. 42, 829 (2009) http://dx.doi.org/10.1016/j.otc.2009.07.005[Crossref]
• [9] S. Türker, E. Onur, Y. Ozer, Pharm. World Sci. 26, 137 (2004) http://dx.doi.org/10.1023/B:PHAR.0000026823.82950.ff[Crossref]
• [10] A. Minn et al., J. Drug Target. 10, 285 (2002) [Crossref]
• [11] Y.C. Wong, Z. Zuo, Pharm. Res. 27, 1208 (2010) http://dx.doi.org/10.1007/s11095-010-0127-5[Crossref]
• [12] M. Alagusundaram, Int. J. Res. Pharm. Sci. 1, 454 (2010)
• [13] R.C. Dhakar, S.D. Maurya, V.K. Tilak, A.K. Gupta, G. Dangi, Int. Res. J. Pharm. 1, 29 (2010)
• [14] M.M. Wen, Discov. Med. 11, 497 (2011)
• [15] L. Illum, J. Pharm. Pharmacol. 56, 3 (2004) http://dx.doi.org/10.1211/0022357022539[Crossref]
• [16] T.K Vyas, A. Shahiwala, S. Marathe, A. Misra, Curr. Drug Deliv. 2, 165 (2005) http://dx.doi.org/10.2174/1567201053586047[Crossref]
• [17] S.V. Dhuria, L.R. Hanson, W.H. 2nd Frey, J. Pharm. Sci. 99, 1654 (2010) [Crossref]
• [18] S. Patel et al., J. Drug Target. 19, 468 (2011) http://dx.doi.org/10.3109/1061186X.2010.523787[Crossref]
• [19] R.I. Henkin, Nat. Biotechnol. 29, 480 (2011) http://dx.doi.org/10.1038/nbt.1866[Crossref]
• [20] Y. Ozsoy, S. Gungor, E. Cevher, Molecules 14, 3754 (2009) http://dx.doi.org/10.3390/molecules14093754[Crossref]
• [21] V.S. Belgamwar et al., Pharm. Dev. Technol. 14, 240 (2009) http://dx.doi.org/10.1080/10837450802498910[Crossref]
• [22] A.H. Elshafeey, E.R. Bendas, O.H. Mohamed, A.A.P.S. Pharm. Sci. Tech. 10, 361 (2009) [Crossref]
• [23] J.C. Garcia-Rodriguez, I. Sosa-Teste, Scientific World Journal 9, 970 (2009) http://dx.doi.org/10.1100/tsw.2009.103[Crossref]
• [24] T.K. Kim et al., Eur. J. Pharm. Sci. 38, 525 (2009) http://dx.doi.org/10.1016/j.ejps.2009.09.019[Crossref]
• [25] H.S. Mahajan, S. Gattani, Drug Deliv. 17, 19 (2009) http://dx.doi.org/10.3109/10717540903447194[Crossref]
• [26] F.C. Carvalho et al., J. Pharm. Pharmacol. 62, 430 (2010) [Crossref]
• [27] R. Jain et al., Nanomedicine (Lond.) 5, 575 (2010) http://dx.doi.org/10.2217/nnm.10.28[Crossref]
• [28] S. Khan, K. Patil, N. Bobade, P. Yeole, R. Gaikwad, J. Drug Target. 18, 223 (2010) http://dx.doi.org/10.3109/10611860903386938[Crossref]
• [29] R. Jain, V.B. Patravale, J. Biomed. Nanotechnol. 5, 62 (2009) http://dx.doi.org/10.1166/jbn.2009.031[Crossref]
• [30] D.J. Pillion, M.D. Fyrberg, E. Meezan, Int. J. Pharm. 388, 202 (2010) http://dx.doi.org/10.1016/j.ijpharm.2010.01.013[Crossref]
• [31] S. Gungor, A. Okyar, S. Erturk-Toker, G. Baktir, Y. Ozsoy, Drug Dev. Ind. Pharm. 36, 806 (2010) http://dx.doi.org/10.3109/03639040903517906[Crossref]
• [32] R. Jain, S. Nabar, P. Dandekar, V. Patravale, Pharm. Res. 27, 655 (2010) http://dx.doi.org/10.1007/s11095-009-0041-x[Crossref]
• [33] M. Kumar, A. Misra, K. Pathak, P.D.A. J. Pharm. Sci. Technol. 63, 501 (2009)
• [34] S. Patil, A. Babbar, R. Mathur, A. Mishra, K. Sawant, J. Drug Target. 18, 321 (2010) http://dx.doi.org/10.3109/10611861003663523[Crossref]
• [35] N.R. Srinivas, Biomed. Chromatogr. 20, 383 (2006) http://dx.doi.org/10.1002/bmc.594[Crossref]
• [36] N.R. Srinivas, Biomed. Chromatogr. 22, 235 (2008) http://dx.doi.org/10.1002/bmc.932[Crossref]
• [37] P.L. Kole, G. Venkatesh, J. Kotecha, R. Sheshala, Biomed. Chromatogr. 25, 199 (2011) http://dx.doi.org/10.1002/bmc.1560[Crossref]
• [38] S. Pandey, P. Pandey, G. Tiwari, R. Tiwari, Pharm. Methods 1, 14 (2010) http://dx.doi.org/10.4103/2229-4708.72223[Crossref]
• [39] C.T. Viswanathan et al., Pharm. Res. 24, 1962 (2007) http://dx.doi.org/10.1007/s11095-007-9291-7[Crossref]
• [40] M. Lim, M.J. Citardi, J.L. Leong, Am. J. Rhinol. 22, 381 (2008) http://dx.doi.org/10.2500/ajr.2008.22.3189[Crossref]
• [41] P. Liu, M. Müller, H. Derendorf, Int. J. Antimicrob. Agents 19, 285 (2002) http://dx.doi.org/10.1016/S0924-8579(02)00024-9[Crossref]
• [42] M. Müller, A. dela Peña, H. Derendorf, Antimicrob. Agents Chemother. 48, 1441 (2004) http://dx.doi.org/10.1128/AAC.48.5.1441-1453.2004[Crossref]
• [43] C.E. Edmiston et al., Surg. Infect. 8, 179 (2007) http://dx.doi.org/10.1089/sur.2006.012[Crossref]
• [44] M. Bimazubute et al., J. Vet. Pharmacol. Ther. 33, 183 (2010) http://dx.doi.org/10.1111/j.1365-2885.2009.01123.x[Crossref]
• [45] M.A. Bimazubute et al., J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 877, 2349 (2009) http://dx.doi.org/10.1016/j.jchromb.2009.01.033[Crossref]
• [46] T.S Kuehnel, C. Schurr, K. Lotter, F. Kees, J. Antimicrob. Chemother. 55, 591 (2005) http://dx.doi.org/10.1093/jac/dki034[Crossref]
• [47] P.B. Dinis, M.C. Monteiro, M.L. Martins, N. Silva, J.G. Morais, Ann. Otol. Rhinol. Laryngol. 113, 142 (2004) [Crossref]
• [48] P. Gehanno et al., J. Antimicrob. Chemother. 49, 821 (2002) http://dx.doi.org/10.1093/jac/dkf014[Crossref]
• [49] F. Pea et al., Pharmacol. Res. 55, 38 (2007) http://dx.doi.org/10.1016/j.phrs.2006.10.003[Crossref]
• [50] A.F. Fang et al., Int. J. Antimicrob. Agents 34, 67 (2009) http://dx.doi.org/10.1016/j.ijantimicag.2009.01.014[Crossref]
• [51] A. Ehnhage, M. Rautiainen, A.F. Fang, S.P. Sanchez. Int. J. Antimicrob. Agents 31, 561 (2008) http://dx.doi.org/10.1016/j.ijantimicag.2008.01.027[Crossref]
• [52] P.B. Dinis, M.C. Monteiro, R. Lobato, M.L. Martins, A. Gomes, Laryngoscope 109, 1841 (1999) http://dx.doi.org/10.1097/00005537-199911000-00023[Crossref]
• [53] P.B. Dinis, M.C. Monteiro, M.L. Martins, N. Silva, A. Gomes, Laryngoscope 110, 1050 (2000) http://dx.doi.org/10.1097/00005537-200006000-00030[Crossref]
• [54] F.G. Hayden, A. Minocha, D.A. Spyker, H.E. Hoffman, Antimicrob. Agents Chemother. 28, 216 (1985) [Crossref]
• [55] M.A. Bimazubute et al., J. Chromatogr. A 1189, 456 (2008) http://dx.doi.org/10.1016/j.chroma.2007.11.011[Crossref]
• [56] U. Jaehde, F. Sörgel, K.G. Naber, J. Zürcher, W. Schunack, Antimicrob. Agents Chemother. 39, 2092 (1995) [Crossref]
• [57] K. Takasaki, K. Enatsu, H. Kumagami, H. Takahashi, Int. J. Otolaryngol. 2009, article ID 495186 (2009), DOI: 10.1155/2009/495186 [Crossref]
• [58] P. Tolsdorff, Infection 21, 66 (1993) http://dx.doi.org/10.1007/BF01739320[Crossref]
• [59] S. Zhang et al., Chem. Res. Toxicol. 22, 949 (2009) http://dx.doi.org/10.1021/tx900040j[Crossref]
• [60] J. Gu et al., Mol. Pharmacol. 67, 623 (2005) http://dx.doi.org/10.1124/mol.104.007898[Crossref]
• [61] G. Mainwaring, J.R. Foster, V. Lund, T. Green, Toxicology 158, 109 (2001) http://dx.doi.org/10.1016/S0300-483X(00)00332-2[Crossref]
• [62] T. Green et al., Chem. Biol. Interact. 137, 185 (2001) http://dx.doi.org/10.1016/S0009-2797(01)00236-8[Crossref]
• [63] Z. Islam, C.J. Amuzie, J.R. Harkema, J.J. Pestka, Toxicol. Sci. 98, 526 (2007) http://dx.doi.org/10.1093/toxsci/kfm102[Crossref]
• [64] B. Casado, Curr. Allergy Asthma Rep. 4, 224 (2004) http://dx.doi.org/10.1007/s11882-004-0030-4[Crossref]
• [65] Y.J. Zhang et al., J. Pharm. Biomed. Anal. 50, 823 (2009) http://dx.doi.org/10.1016/j.jpba.2009.06.043[Crossref]
• [66] K. Go et al., Auris Nasus Larynx 37, 427 (2010) http://dx.doi.org/10.1016/j.anl.2009.10.005[Crossref]
• [67] B. Ghafouri, E. Kihlström, B. Ståhlbom, C. Tagesson, M. Lindahl, Biochem. Soc. Trans. 31, 810 (2003) http://dx.doi.org/10.1042/BST0310810[Crossref]
• [68] H. Riechelmann et al., Clin. Exp. Allergy 35, 1186 (2005) http://dx.doi.org/10.1111/j.1365-2222.2005.02316.x[Crossref]
• [69] Y.S. Cho, S.Y. Park, C.K. Lee, B. Yoo, H.B. Moon, J. Allergy Clin. Immunol. 112, 695 (2003) http://dx.doi.org/10.1016/S0091-6749(03)01784-6[Crossref]
• [70] C. Bachert, M.J. van Kempen, K. Höpken, G. Holtappels, M. Wagenmann, Eur. Arch. Otorhinolaryngol. 258, 406 (2001) http://dx.doi.org/10.1007/s004050100363[Crossref]
• [71] S.J. Wilson, L. Lau, P.H. Howarth, Clin. Exp. Allergy 28, 220 (1998) http://dx.doi.org/10.1046/j.1365-2222.1998.00235.x[Crossref]
• [72] R. Dahl, N. Mygind, Adv. Drug Deliv. Rev. 29, 3 (1998) http://dx.doi.org/10.1016/S0169-409X(97)00058-6[Crossref]
• [73] S. Gizurarson, Acta Pharm. Nord. 2, 105 (1990)
• [74] N. Jones, Adv. Drug Deliv. Rev. 51, 5 (2001) http://dx.doi.org/10.1016/S0169-409X(01)00172-7[Crossref]
• [75] H. Petersen, A. Kullberg, S. Edsbäcker, L. Greiff, Br. J. Clin. Pharmacol. 51, 159 (2001) [Crossref]
• [76] H. Sato et al., B.M.C. Pharmacol. 7, 7 (2007)
• [77] H. Sato et al., Biopharm. Drug Dispos. 28, 59 (2007) http://dx.doi.org/10.1002/bdd.531[Crossref]
• [78] Y. Zhang et al., Biol. Pharm. Bull. 28, 2263 (2005) http://dx.doi.org/10.1248/bpb.28.2263[Crossref]
• [79] K. Stoeckel, M. Harell, M. Dan, Antimicrob. Agents Chemother. 40, 780 (1996)
• [80] M.D. Alahmari, R.J. Sapsford, J.A. Wedzicha, J.R. Hurst, Transl. Res. 158, 163 (2011) http://dx.doi.org/10.1016/j.trsl.2011.04.001[Crossref]
• [81] D.P. Calfee, A.W. Peng, E.K. Hussey, M. Lobo, F.G. Hayden, Antivir. Ther. 4, 143 (1999)
• [82] P. Karma, J. Pukander, M. Penttilä, Eur. J. Clin. Microbiol. Infect. Dis. 10, 856 (1991) http://dx.doi.org/10.1007/BF01975841[Crossref]
• [83] M. Stenquist, L. Olen, M. Jannert, L. Näslund, M.L. Zeckel, Clin. Ther. 18, 273 (1996) http://dx.doi.org/10.1016/S0149-2918(96)80008-7[Crossref]
• [84] G. Petrikkos, P. Goumas, E. Moschovakis, H. Giamarellou, Eur. J. Clin. Microbiol. Infect. Dis. 11, 828 (1992) http://dx.doi.org/10.1007/BF01960883[Crossref]
• [85] J.B. Watelet, P. Gevaert, G. Holtappels, P. Van Cauwenberge, C. Bachert, Eur. Arch. Otorhinolaryngol. 261, 243 (2004) http://dx.doi.org/10.1007/s00405-003-0691-y[Crossref]
• [86] H. Riechelmann, T. Deutschle, E. Friemel, H.J. Gross, M. Bachem, Eur. Respir. J. 21, 600 (2003) http://dx.doi.org/10.1183/09031936.03.00072003[Crossref]
• [87] F.X. Lü, R.E. Esch, J. Immunol. Methods 356, 6 (2010) http://dx.doi.org/10.1016/j.jim.2010.03.004[Crossref]
• [88] L. Nikasinovic-Fournier et al., J. Lab. Clin. Med. 139, 173 (2002) http://dx.doi.org/10.1067/mlc.2002.121661[Crossref]
• [89] E.E. Walsh, A.R. Falsey, J. Infect. Dis. 179, 1268 (1999) http://dx.doi.org/10.1086/314726[Crossref]
• [90] L. Klimek, G. Rasp, Clin. Exp. Allergy 29, 367 (1999) http://dx.doi.org/10.1046/j.1365-2222.1999.00494.x[Crossref]
• [91] T. Frischer, E. Baraldi, Am. J. Respir. Crit. Care Med. 162, 28 (2000) [Crossref]
• [92] P.G. Ambrose et al., Clin. Infect. Dis. 38, 1513 (2004) http://dx.doi.org/10.1086/420739[Crossref]
• [93] P.G. Ambrose et al., Diagn. Microbiol. Infect. Dis. 61, 13 (2008) http://dx.doi.org/10.1016/j.diagmicrobio.2008.01.010[Crossref]
• [94] J.B. Anon et al., Diagn. Microbiol. Infect. Dis. 57, 105 (2007) http://dx.doi.org/10.1016/j.diagmicrobio.2006.10.019[Crossref]
• [95] E.A. Piercy, R.E. Bawdon, P.A. Mackowiak, Antimicrob. Agents Chemother. 33, 1645 (1989) [Crossref]
• [96] Y.F. Chung, M.D. Donovan, Int. J. Pharm. 128, 229 (1996) http://dx.doi.org/10.1016/0378-5173(95)04313-6[Crossref]
• [97] A.M. Sanico, G. Philip, G.K. Lai, A. Togias, J. Appl. Physiol. 86, 1202 (1999) http://dx.doi.org/10.1063/1.370871[Crossref]
• [98] B. Garré et al., J. Vet. Pharmacol. Ther. 32, 207 (2009) http://dx.doi.org/10.1111/j.1365-2885.2008.01025.x[Crossref]
• [99] C. Friis, Am. J. Vet. Res. 54, 1122 (1993)
• [100] P. Mämmelä et al., J. Environ. Monit. 4, 187 (2002) http://dx.doi.org/10.1039/b110882d[Crossref]
• [101] I. Ramis et al., J. Chromatogr. 532, 217 (1990) http://dx.doi.org/10.1016/S0378-4347(00)83773-1[Crossref]
• [102] E. Millqvist, E. Ternesten-Hasséus, A. Ståhl, M. Bende, Environ. Health Perspect. 113, 849 (2005) http://dx.doi.org/10.1289/ehp.7657[Crossref]
• [103] T. Heikkinen, M. Shenoy, R.M. Goldblum, T. Chonmaitree, Pediatr. Res. 45, 230 (1999) http://dx.doi.org/10.1203/00006450-199902000-00012[Crossref]
• [104] P.A. Dargaville, M. South, P. Vervaart, P.N. McDougall, Am. J. Respir. Crit. Care Med. 160, 778 (1999) [Crossref]
• [105] H.C. Kaulbach, M.V. White, Y. Igarashi, B.K. Hahn, M.A. Kaliner, J. Allergy Clin. Immunol. 92, 457 (1993) http://dx.doi.org/10.1016/0091-6749(93)90125-Y[Crossref]
• [106] C. Ward et al., Thorax 48, 518 (1993) http://dx.doi.org/10.1136/thx.48.5.518[Crossref]
• [107] T.W. Marcy, W.W. Merrill, J.A. Rankin, H.Y. Reynolds, Am. Rev. Respir. Dis. 135, 1276 (1987) [Crossref]
• [108] N. Kirschvink et al., Vet. Res. 32, 145 (2001) http://dx.doi.org/10.1051/vetres:2001117[Crossref]
• [109] A. Virolainen et al., J. Clin. Microbiol. 31, 1382 (1993)
• [110] L. Nováková, H. Vlčková. Anal. Chim. Acta 656, 8 (2009) http://dx.doi.org/10.1016/j.aca.2009.10.004[Crossref]
• [111] A. Maes et al., Biomed. Chromatogr. 23, 132 (2009) http://dx.doi.org/10.1002/bmc.1093[Crossref]
• [112] R. Wyss, F. Bucheli, J. Chromatogr. 430, 81 (1988) http://dx.doi.org/10.1016/S0378-4347(00)83136-9[Crossref]
• [113] P. Cherrier et al., Eur. J. Clin. Microbiol. Infect. Dis. 12, 211 (1993) http://dx.doi.org/10.1007/BF01967115[Crossref]
• [114] F. Kees, W. Raasch, M. Steger, H. Grobecker, J. Chromatogr. 525, 484 (1990) http://dx.doi.org/10.1016/S0378-4347(00)83428-3[Crossref]
• [115] F. Camus, A. Deslandes, L. Harcouet, R. Farinotti, J. Chromatogr. B Biomed. Appl. 656, 383 (1994) http://dx.doi.org/10.1016/0378-4347(94)00122-7[Crossref]
• [116] P. Krumpe, C.C. Lin, E. Radwanski, M.N. Cayen, M.B. Affrime, Chest 116, 369 (1999) http://dx.doi.org/10.1378/chest.116.2.369[Crossref]
• [117] B. Joos et al., Antimicrob. Agents Chemother. 27, 353 (1985) [Crossref]
• [118] E. Weidekamm, R. Portmann, Am. J. Med. 94, 75 (1993) http://dx.doi.org/10.1016/0002-9343(93)90123-7[Crossref]
• [119] H. Stass, A. Dalhoff, J. Chromatogr. B Biomed. Sci Appl. 702, 163 (1997) http://dx.doi.org/10.1016/S0378-4347(97)00371-X[Crossref]
• [120] V. Gudziol, J. Pietsch, M. Witt, T. Hummel, Eur. Arch. Otorhinolaryngol. 267, 239 (2010) http://dx.doi.org/10.1007/s00405-009-1076-7[Crossref]
• [121] R.J. England, J.J. Homer, L.C. Knight, S.R. Ell, Clin. Otolaryngol. Allied Sci. 24, 67 (1999) http://dx.doi.org/10.1046/j.1365-2273.1999.00223.x[Crossref]
• [122] M.I. Ugwoke, N. Verbeke, R. Kinget, J. Pharm. Pharmacol. 53, 3 (2001) http://dx.doi.org/10.1211/0022357011775145[Crossref]
• [123] D.E. Nix, S.D. Goodwin, C.A. Peloquin, D.L. Rotella, J.J. Schentag, Antimicrob. Agents Chemother. 35, 1947 (1991) [Crossref]
• [124] R.N. Xu, L. Fan, M.J. Rieser, T.A. El-Shourbagy, J. Pharm. Biomed. Anal. 44, 342 (2007) http://dx.doi.org/10.1016/j.jpba.2007.02.006[Crossref]
• [125] P. Campíns-Falcó, R. Herráez-Hernández, A. Sevillano-Cabeza, J. Chromatogr. 619, 177 (1993) http://dx.doi.org/10.1016/0378-4347(93)80107-F[Crossref]
• [126] M. Abdel-Rehim, Anal. Chim. Acta 701, 119 (2011) http://dx.doi.org/10.1016/j.aca.2011.05.037[Crossref]
• [127] F. Fraschini et al., J. Antimicrob. Chemother. 27, 61 (1991) [Crossref]
• [128] G. Kment, A. Georgopoulos, W. Ridl, J. Mühlbacher, Eur. Arch. Otorhinolaryngol. 252, 236 (1995) http://dx.doi.org/10.1007/BF00179917[Crossref]
• [129] S.E. Holm, A.M. Bergholm, C. Ekedahl, K. Lundin, J. Laryngol. Otol. 97, 59 (1983) http://dx.doi.org/10.1017/S0022215100093816[Crossref]
• [130] D. Sharma, R. Mittal, A. Gupta, K. Singh, A. Nair, J. Pharmaceut. Biomed. Sci. 7, 1 (2010)
• [131] L. Nováková, L. Matysová, P. Solich, Talanta 68, 908 (2006) http://dx.doi.org/10.1016/j.talanta.2005.06.035[Crossref]
• [132] M. Vogeser, C. Seger, Clin. Biochem. 41, 649 (2008) http://dx.doi.org/10.1016/j.clinbiochem.2008.02.017[Crossref]
• [133] D.M. Müller, K.M. Rentsch, Anal. Bioanal. Chem. 398, 2573 (2010) http://dx.doi.org/10.1007/s00216-010-3986-z[Crossref]
• [134] P. Wall, B. Kumar, A. Bhandari, A.K. Rai, A. Wal, J. Pharmaceut. Sci. Technol. 2, 333 (2010)
• [135] M. Jemal, Biomed. Chromatogr. 14, 422 (2000) http://dx.doi.org/10.1002/1099-0801(200010)14:6<422::AID-BMC25>3.0.CO;2-I[Crossref]
• [136] B.K. Matuszewski, M.L. Constanzer, C.M. Chavez-Eng, Anal. Chem. 75, 3019 (2003) http://dx.doi.org/10.1021/ac020361s[Crossref]
• [137] J. Gu et al., J. Pharmacol. Exp. Ther. 285, 1287 (1998)
• [138] M.B. Genter et al., Biochem. Pharmacol. 55, 1819 (1998) http://dx.doi.org/10.1016/S0006-2952(98)00004-5[Crossref]
• [139] S. Bansal, A. DeStefano, A.A.P.S. J. 9, 109 (2007)
• [140] V.P. Shah et al., Pharm. Res. 17, 1551 (2000) http://dx.doi.org/10.1023/A:1007669411738[Crossref]
• [141] Guidance for Industry: Bioanalytical method validation (US Food and Drug Administration, USA, 2001) http://www.fda.gov/downloads/Drugs/GuidanceComplianceRegulatoryInformation/Guidances/UCM070107.pdf

Identifiers

DOI

10.2478/s11532-012-0021-6