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Journal

2012 | 10 | 2 | 305-312

Article title

Development of cephalexin-loaded poly(ethyl cyanoacrylate) colloidal nanospheres

Authors

Content

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Languages of publication

EN

Abstracts

EN
This article considers the preparation and physicochemical characterization of a novel colloidal formulation of the β-lactam antibiotic cephalexin, loaded in poly(ethyl cyanoacrylate) colloidal nanospheres. The drug was loaded by means of drug incorporation in the interior of poly(ethyl cyanoacrylate) particles during the polymerization of the respective monomer in aqueous medium. The obtained colloids were characterized by scanning electron microscopy, dynamic and electrophoretic light scattering, Fourier transform infrared and nuclear magnetic resonance spectroscopy. It was found that the drug loading efficiency depends on the initial concentration of monomer and cephalexin in the polymerization medium. The average size of cephalexin-loaded particles was around 400 nm and did not depend significantly on the concentrations of drug and monomer. Drug-loaded particles with drug content as high as 21% (w/w) were prepared. The drug release kinetics was studied in physiological phosphate-buffered saline. It was found that a biexponential model could describe well the experimental release kinetics. [...]

Publisher

Journal

Year

Volume

10

Issue

2

Pages

305-312

Physical description

Dates

published
1 - 4 - 2012
online
29 - 1 - 2012

Contributors

  • Faculty of Chemistry, Sofia University “St. Kliment Ohridski”, 1164, Sofia, Bulgaria

References

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Document Type

Publication order reference

Identifiers

YADDA identifier

bwmeta1.element.-psjd-doi-10_2478_s11532-011-0143-2
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