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Journal
2012 | 10 | 2 | 320-326
Article title

Binuclear copper complexes with non-steroidal anti-inflammatory drugs as studied by electrospray ionization mass spectrometry

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EN
Abstracts
EN
The solutions containing one of the copper salts (CuCl2, Cu(ClO4)2, Cu(NO3)2, and CuSO4) and one of the non-steroidal anti-inflammatory drugs (NSAIDs, ibuprofen, ketoprofen or naproxen) were analyzed by electrospray ionization mass spectrometry. Three of the salts, namely CuCl2, Cu(ClO4)2 and Cu(NO3)2, yielded binuclear complexes of drug:metal stoichiometry 1:2. Existence of the complexes of such stoichiometry has not been earlier observed. For copper(II) chloride the complexes (ions of the type [M-HCOOH+Cu2Cl]+ and [M+Cu2Cl]+, M stands for the drug molecule) were formed in the gas phase. When copper(II) perchlorate or copper(II) nitrate was used, the observed binuclear copper complexes (ions of the type [M-H+Cu2(ClO4)2+CH3OH]+, [M-H+Cu2(ClO4)2]+ and [M-H+Cu2(NO3)2+CH3OH]+, [M-H+Cu2(NO3)2]+) were observed at low cone voltage, thus these complexes must have already existed in the solution analysed. Therefore, such complexes may also exist under physiological conditions. [...]
Publisher

Journal
Year
Volume
10
Issue
2
Pages
320-326
Physical description
Dates
published
1 - 4 - 2012
online
29 - 1 - 2012
Contributors
author
  • Faculty of Chemistry, Adam Mickiewicz University, 60-780, Poznań, Poland
  • Institute of Chemistry, Poznań University of Technology, 60-965, Poznań, Poland
  • Faculty of Chemistry, Adam Mickiewicz University, 60-780, Poznań, Poland, franski@amu.edu.pl
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Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.-psjd-doi-10_2478_s11532-011-0139-y
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