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Journal
2012 | 10 | 1 | 187-193
Article title

Spectrophotometric studies of the reaction of quercetin with peroxynitrite at different pH

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EN
Abstracts
EN
Peroxynitrite (ONOOH/ONOO-) which is formed in vivo under oxidative stress is a strong oxidizing and nitrating agent. It has been reported that several flavonoids, including quercetin, inhibit the peroxynitrite-induced oxidation and/or nitration of several molecules tested; however, the mechanism of their protective action against peroxynitrite is not univocally resolved. The kinetics of the reaction of quercetin with peroxynitrite was studied by stopped-flow as well as by conventional spectrophotometry under acidic, neutral and alkaline pH. The obtained results show that the protective mechanism of quercetin against peroxynitrite toxicity cannot be explained by direct scavenging of peroxynitrite. We propose that quercetin acts via scavenging intermediate radical products of peroxynitrite decomposition (it is an excellent scavenger of ┬ĚNO2) and/or via reduction of target radicals formed in the reaction with peroxynitrite.
Publisher
Journal
Year
Volume
10
Issue
1
Pages
187-193
Physical description
Dates
published
1 - 2 - 2012
online
24 - 11 - 2011
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Document Type
Publication order reference
YADDA identifier
bwmeta1.element.-psjd-doi-10_2478_s11532-011-0125-4
Identifiers
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