Stability-indicating derivative spectrophotometry method for the determination of biapenem in the presence of its degradation products

• Authors: Judyta Cielecka-Piontek , Aran Lunzer , Anna Jelińska
• Languages of publication: EN

Abstracts

EN

A first-derivative UV spectrophotometric method, with or without the subtraction technique, was developed for the determination of biapenem in pharmaceutical dosage form in the presence of its degradation products. The method was based on the measurement of first-derivative amplitudes at zero crossing point (λ = 312 nm) and the peak-to-zero technique and validated with regard to linearity, limits of detection and quantitation, selectivity and precision. The observed rate constants for the degradation of biapenem were comparable to those obtained in the stability-indicating HPLC method. [...]

Keywords

EN

Biapenem; Degradation; First-derivative UV

• Publisher: De Gruyter Open
• Journal: Open Chemistry
• Year: 2011
• Volume: 9
• Issue: 1
• Pages: 35-40

Dates

published

1 - 2 - 2011

online

16 - 12 - 2010

Contributors

author

Judyta Cielecka-Piontek

• Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Poznan University of Medical Sciences, 60-780, Poznań, Poland

author

Aran Lunzer

• Tanaka Laboratory in Hokkaido University, W7, Kita-ku, Sapporo, 060-8638, Japan

author

Anna Jelińska

• Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Poznan University of Medical Sciences, 60-780, Poznań, Poland

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Identifiers

DOI

10.2478/s11532-010-0125-9