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Journal
2011 | 9 | 1 | 66-74
Article title

The thermodynamic dissociation constant of naphazoline by the regression analysis of potentiometric data

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EN
Abstracts
EN
The mixed dissociation constant of naphazoline is determined at various ionic strengths I [mol dm−3] in the range of 0.01 to 0.26 and at temperatures of 25°C and 37°C using ESAB and HYPERQUAD regression analysis of the potentiometric titration data. A strategy of efficient experimentation is proposed in a protonation constant determination, followed by a computational strategy for the chemical model with a protonation constant determination. Two group parameters, L 0 and H T were ill-conditioned in the model and their determination is therefore uncertain. These group parameters, L 0 and H T, can significantly influence a systematic error in the estimated common parameter pKa and they always should be refined together with pK a. The thermodynamic dissociation constant pK aT was estimated by nonlinear regression of {pK a, I} data at 25°C and 37°C: for naphazoline pK alT = 10.41(1) and 10.13(2). Goodness-of-fit tests for various regression diagnostics enabled the reliability of the parameter estimates to be found. [...]
Publisher
Journal
Year
Volume
9
Issue
1
Pages
66-74
Physical description
Dates
published
1 - 2 - 2011
online
16 - 12 - 2010
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Document Type
Publication order reference
YADDA identifier
bwmeta1.element.-psjd-doi-10_2478_s11532-010-0117-9
Identifiers
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