Alkyl methylphosphonic acids, the degradation products of organophosphorous CWA - preparation and direct quantitative GC-FID analysis

• Authors: Iwona Połeć , Anna Kiełczewska , Leszek Konopski , Grażyna Oleksa , Hanna Krukowska , Jan Legocki
• Languages of publication: EN

Abstracts

EN

Seven alkyl methylphosphonic acids, products of hydrolytic degradation of organophosphorus chemical warfare agents, were obtained with a high purity (mostly above 98%), with the aim of being applyed as future certified reference materials. Ethyl (EMPA), isopropyl (IMPA), pinacolyl (PMPA), butyl (BUMPA), isobutyl (IBUMPA), cyclohexyl (CHMPA) and 2-ethylhexyl (EHMPA) monoesters of MPA were synthesized and characterized by MS EI, FTIR and NMR (1H, 13C, 31P), TLC, as well as GC and GC-MS after derivatization. The conditions for a direct quantitative GC FID analysis on CP-FFAP CB column of non-derivatized alkyl methylphosphonic acids were developed. This is the first successful attempt of a directed GC analysis of free alkyl phosphonic acids. Their chemical purity was determined and limit of quantification (LOQ) values for some of them were evaluated for the GC-FID method.

Keywords

EN

Organophosphorus chemical warfare agents; Degradation products; Alkyl methylphosphonic acids; Gas chromatography; Reference materials

• Publisher: De Gruyter Open
• Journal: Open Chemistry
• Year: 2010
• Volume: 8
• Issue: 6
• Pages: 1251-1265

Dates

published

1 - 12 - 2010

online

8 - 10 - 2010

Contributors

author

Iwona Połeć

• Institute of Industrial Organic Chemistry, 03-236, Warsaw, Poland

author

Anna Kiełczewska

• Institute of Industrial Organic Chemistry, 03-236, Warsaw, Poland

author

Leszek Konopski

• Institute of Industrial Organic Chemistry, 03-236, Warsaw, Poland

author

Grażyna Oleksa

• Institute of Industrial Organic Chemistry, 03-236, Warsaw, Poland

author

Hanna Krukowska

• Institute of Industrial Organic Chemistry, 03-236, Warsaw, Poland

author

Jan Legocki

• Institute of Industrial Organic Chemistry, 03-236, Warsaw, Poland

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Identifiers

DOI

10.2478/s11532-010-0102-3