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Journal
2010 | 8 | 4 | 937-945
Article title

Construction of different types of ion-selective electrodes and validation of direct potentiometric determination of phenytoin sodium

Content
Title variants
Languages of publication
EN
Abstracts
EN
The construction and performance characteristics of phenytoin sodium selective electrodes are detailed. Two types of electrodes: plastic membrane I and coated wire II, were constructed based on the incorporation of phenytoin sodium with tungstosilicic acid. The influence of membrane composition, kind of plasticizer, pH of the test solution, soaking time and the electrodes’ foreign ions were investigated. The electrodes showed a Nernstian response with a mean calibration graph slope of 30.9±0.1 and 28.9±0.1 mV decade−1 at 25°C for electrode I and II respectively, over a phenytoin sodium concentration range of 5×10−3−5×10−6 M and 1×10−3−1×10−6 M with a detection limit 1.3×10−6 M and 2.5×10−7 M for electrode I and II, respectively. The electrodes gave average selective precision and were usable within the pH range 6–10. Interference studies from common cations, alkaloids, sugars, amino acids and drug excipients are reported. The results obtained by the proposed electrodes were also applied successfully for the determination of the drug in pharmaceutical preparations and biological fluids.
Publisher

Journal
Year
Volume
8
Issue
4
Pages
937-945
Physical description
Dates
published
1 - 8 - 2010
online
17 - 6 - 2010
Contributors
  • Analytical Chemistry Department, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt
author
  • Analytical Chemistry Department, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt
  • Analytical Chemistry Department, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt
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Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.-psjd-doi-10_2478_s11532-010-0064-5
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