Inclusion complexes of amlodipine besylate and cyclodextrins

• Authors: Agneš Kapor , Vesna Nikolić , Ljubiša Nikolić , Mihajlo Stanković , Milorad Cakić , Ljiljana Stanojević , Dušica Ilić
• Languages of publication: EN

Abstracts

EN

In this paper the procedure for the preparation of inclusion complexes of amlodipine besylate with β-cyclodextrin (β-CD) and 2-hydrohypropyl-β-cyclodextrin (HPβ-CD) and their structural characterization was described. Molecular inclusion complexes of amlodipine besylate are prepared by the coprecipitation method and characterised by the application of spectroscopic methods FTIR, 1H-NMR and XRD. The photosensitivity of amlodipine besylate in the inclusion complexes was also determined with respect to uncomplexed agent. DSC curves indicate the loss of the clear peak due to melting of amlodipine besylate at about 200°C, while on XR diffractograms certain reflections are lost belonging to amlodipine besylate in complexes. This indicates its inclusion in the vacancies of the host. The inclusion of amlodipine besylate with cyclodextrins increases the stability, i.e. decreases the photosensitivity of amlodipine besylate. [...]

Keywords

EN

Amlodipine besylate; Inclusion complexes; Cyclodextrins; Spectroscopic methods; Photosensitivity

• Publisher: De Gruyter Open
• Journal: Open Chemistry
• Year: 2010
• Volume: 8
• Issue: 4
• Pages: 834-841

Dates

published

1 - 8 - 2010

online

17 - 6 - 2010

Contributors

author

Agneš Kapor

• Faculty of Sciences, Department of Physics, University of Novi Sad, 21000, Novi Sad, Serbia

author

Vesna Nikolić

• Faculty of Technology, University of Nis, 16000, Leskovac, Serbia

author

Ljubiša Nikolić

• Faculty of Technology, University of Nis, 16000, Leskovac, Serbia

author

Mihajlo Stanković

• Faculty of Technology, University of Nis, 16000, Leskovac, Serbia

author

Milorad Cakić

• Faculty of Technology, University of Nis, 16000, Leskovac, Serbia

author

Ljiljana Stanojević

• Faculty of Technology, University of Nis, 16000, Leskovac, Serbia

author

Dušica Ilić

• Faculty of Technology, University of Nis, 16000, Leskovac, Serbia

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Identifiers

DOI

10.2478/s11532-010-0061-8