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Journal
2010 | 8 | 4 | 834-841
Article title

Inclusion complexes of amlodipine besylate and cyclodextrins

Content
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EN
Abstracts
EN
In this paper the procedure for the preparation of inclusion complexes of amlodipine besylate with β-cyclodextrin (β-CD) and 2-hydrohypropyl-β-cyclodextrin (HPβ-CD) and their structural characterization was described. Molecular inclusion complexes of amlodipine besylate are prepared by the coprecipitation method and characterised by the application of spectroscopic methods FTIR, 1H-NMR and XRD. The photosensitivity of amlodipine besylate in the inclusion complexes was also determined with respect to uncomplexed agent. DSC curves indicate the loss of the clear peak due to melting of amlodipine besylate at about 200°C, while on XR diffractograms certain reflections are lost belonging to amlodipine besylate in complexes. This indicates its inclusion in the vacancies of the host. The inclusion of amlodipine besylate with cyclodextrins increases the stability, i.e. decreases the photosensitivity of amlodipine besylate. [...]
Publisher

Journal
Year
Volume
8
Issue
4
Pages
834-841
Physical description
Dates
published
1 - 8 - 2010
online
17 - 6 - 2010
Contributors
author
  • Faculty of Sciences, Department of Physics, University of Novi Sad, 21000, Novi Sad, Serbia, akapor@df.uns.ac.rs
  • Faculty of Technology, University of Nis, 16000, Leskovac, Serbia
  • Faculty of Technology, University of Nis, 16000, Leskovac, Serbia
  • Faculty of Technology, University of Nis, 16000, Leskovac, Serbia
  • Faculty of Technology, University of Nis, 16000, Leskovac, Serbia
  • Faculty of Technology, University of Nis, 16000, Leskovac, Serbia
author
  • Faculty of Technology, University of Nis, 16000, Leskovac, Serbia
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Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.-psjd-doi-10_2478_s11532-010-0061-8
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