Synthesis and characterization of molecularly imprinted polymer for controlled release of tramadol

• Authors: Saman Azodi-Deilamia , Majid Abdoussa , S. Rezvaneh Seyedib
• Languages of publication: EN

Abstracts

EN

In this paper, we describe how to prepare a highly selective imprinted polymer by a bulk polymerization technique. We used tramadol as the template, (MAA) as functional monomers, and (EGDMA) as the cross-linker in chloroform as solvent. Results from Fourier Transform Infrared Spectroscopy (FTIR), Thermogravimetric Analysis (TGA), Scanning Electron microscopy (SEM) show that this imprinted sorbent exhibits good recognition and high affinity for tramadol. Selectivity of molecularly imprinted polympers (MIP) was evaluated by comparing several substances with similar molecular structures to that of tramadol. Controlled release of tramadol from MIPs was investigated through in vitro dissolution tests and by measuring the absorbance at λmax of 272 nm by (HPLC-UV). The dissolution media employed were hydrochloric acid pH 3.0 and phosphate buffers, pH 5.0 and 7.4, maintained at 37 and 25 ± 0.5°C. The results show the ability of MIP polymers to control tramadol release. In all cases, the release of MIPs was deferred for a longer time as compared to NMIP. At a pH of 7.4 and 25°C slower release of tramadol imprinted polymer occurred. [...]

Keywords

EN

Molecularly; Imprinted polymer; Tramadol; Bulk polymerization; Drug release; Biological systems

• Publisher: De Gruyter Open
• Journal: Open Chemistry
• Year: 2010
• Volume: 8
• Issue: 3
• Pages: 687-695

Dates

published

1 - 6 - 2010

online

25 - 4 - 2010

Contributors

author

Saman Azodi-Deilamia

• Department of Chemistry, Amirkabir University of Technology, Hafez 424, Tehran, P.O. Box 15875-4413, Iran

author

Majid Abdoussa

• Department of Chemistry, Amirkabir University of Technology, Hafez 424, Tehran, P.O. Box 15875-4413, Iran

author

S. Rezvaneh Seyedib

• Department of Chemistry, College of Science, Semnan University, Semnan, Iran

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Identifiers

DOI

10.2478/s11532-010-0035-x