Synthesis and characterization of new copper(II) complex compounds with chlorhexidine. Part I

• Authors: Mirela Călinescu , Ticuţa Negreanu-Pîrjol , Rodica Georgescu , Octavian Călinescu
• Languages of publication: EN

Abstracts

EN

Three new copper(II) complex compounds with chlorhexidine diacetate as a ligand have been prepared and characterized by elemental and thermogravimetrical analyses, molar conductances, magnetic susceptibility measurements, infrared, electronic and EPR spectra. The complexes correspond to the formulas: [Cu2(CHX)Cl4]·2C2H5OH, [Cu2(CHX)Br4]·2C2H5OH and [Cu2(CHX)(CH3COO)2] (CH3COO)2·2C2H5OH, where CHX = chlorhexidine, their composition and stereochemistry depending on the reaction conditions and the metal salt used. Chlorhexidine acts as neutral tetradentate NNNN donor, coordinating through the four imine nitrogen atoms. Investigations on antimicrobial activity in vitro show that all the complexes are active against the tested microorganisms, the complex with chloride being more active against Gram negative bacteria than chlorhexidine diacetate.. [...]

Keywords

EN

Biguanides; Chlorhexidine; Copper(II) complexes

• Publisher: De Gruyter Open
• Journal: Open Chemistry
• Year: 2010
• Volume: 8
• Issue: 3
• Pages: 543-549

Dates

published

1 - 6 - 2010

online

25 - 4 - 2010

Contributors

author

Mirela Călinescu

• Faculty of Chemistry, University of Bucharest, Bucharest, 020462, Romania

author

Ticuţa Negreanu-Pîrjol

• Faculty of Pharmacy, Ovidius University, Constanţa, 900470, Romania

author

Rodica Georgescu

• Research Development National Institute for Physics and Nuclear, Engineering Horia Hulubei, Bucharest-Măgurele, 077125, Romania

author

Octavian Călinescu

• Faculty of Chemistry, University of Bucharest, Bucharest, 020462, Romania

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Identifiers

DOI

10.2478/s11532-010-0028-9