Synthesis, characterization and antitumor activity of Cu(II), Co(II), Zn(II) and Mn(II) complex compounds with aminothiazole acetate derivative

• Authors: Maria-Gabriela Alexandru , Tanja Velickovic , Ioana Jitaru , Sanja Grguric-Sipka , Constantin Draghici
• Languages of publication: EN

Abstracts

EN

This paper presents the synthesis of complex compounds of type [M(L1)2], where M(II)= Cu (1), Co (2), Zn (3), L1=2-aminothiazole-4-acetate and [Mn(L1)2(H2O)] (4) using ethyl 2-(2-aminothiazole-4-yl) acetate (L), and characterization by elemental analysis, magnetic susceptibilities, IR, 1H-NMR, UV-Vis spectroscopy and for [Mn(L1)2(H2O)] also by X-ray diffraction. In vitro cytotoxicity studies were performed on human cervix adenocarcinoma, HeLa cells. The antitumor selectivity was assessed using normal human peripheral blood mononuclear cells, PBMC as control. [...]

Keywords

EN

Aminothiazole; Cytotoxicity; HeLa; PBMC

• Journal: Open Chemistry
• Year: 2010
• Volume: 8
• Issue: 3
• Pages: 639-645

Dates

published

1 - 6 - 2010

online

25 - 4 - 2010

Contributors

author

Maria-Gabriela Alexandru

• Inorganic Chemistry Department, University “Politehnica” of Bucharest, 011061, Bucharest, Romania,

author

Tanja Velickovic

• Department of Biochemistry, University of Belgrade, Faculty of Chemistry, 11000, Belgrade, Serbia

author

Ioana Jitaru

• Inorganic Chemistry Department, University “Politehnica” of Bucharest, 011061, Bucharest, Romania

author

Sanja Grguric-Sipka

• Faculty of Chemistry, Department of Inorganic Chemistry, University of Belgrade, 11000, Belgrade, Serbia

author

Constantin Draghici

• C.D. Nenitescu Center of Organic Chemistry of the Romanian Academy, 71141, Bucharest, Romania

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Identifiers

DOI

10.2478/s11532-010-0022-2