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Number of results

Journal

2010 | 8 | 3 | 536-542

Article title

Surfactant to dye binding degree method for the determination of fluvoxamine maleate and citalopram hydrobromide in pharmaceuticals

Content

Title variants

Languages of publication

EN

Abstracts

EN
The surfactant to dye binding degree (SBDB) methodology was used to determine fluvoxamine maleate and citalopram hydrobromide. Neutral red and sodium dodecyl sulfate (SDS) were used as the dye and surfactant, respectively, to form dye-surfactant aggregates. When a cationic drug is added to dye-surfactant mixture, it interacts with the surfactant and decreases the dye-surfactant binding degree. This decrease is proportional to the drug concentration. This was measured by monitoring the absorbance changes of the dye at 532 nm. Under the optimum conditions, the calibration graphs were linear over the range of 1.2–15 μg mL−1 and 1.1–15 μg mL−1 for fluvoxamine maleate and citalopram hydrobromide, respectively. The detection limits (signal to noise ratio = 3) were found to be 0.37 and 0.35 μg mL−1, for fluvoxamine maleate and citalopram hydrobromide, respectively. [...]

Publisher

Journal

Year

Volume

8

Issue

3

Pages

536-542

Physical description

Dates

published
1 - 6 - 2010
online
25 - 4 - 2010

Contributors

  • Department of Analytical Chemistry, Faculty of Chemistry, University of Tabriz, Tabriz, Iran
  • Department of Analytical Chemistry, Faculty of Chemistry, University of Tabriz, Tabriz, Iran
  • Department of Analytical Chemistry, Faculty of Chemistry, University of Tabriz, Tabriz, Iran

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Document Type

Publication order reference

Identifiers

YADDA identifier

bwmeta1.element.-psjd-doi-10_2478_s11532-010-0011-5
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