PL EN


Preferences help
enabled [disable] Abstract
Number of results
Journal
2010 | 8 | 1 | 96-107
Article title

Synthesis, characterization and biological activities of homo-binuclear Cu(II) and Zn(II) complexes derived from 2-hydroxy-5-methyl-1,3-benzenedicarboxaldehyde derivatives

Content
Title variants
Languages of publication
EN
Abstracts
EN
Few novel binuclear Schiff base metal complexes [M2LCl3], where M = Cu(II) and Zn(II); L= 2,6-bis-({2-[(3-hydroxy-4-nitrobenzylidene)amino]ethylimino}methyl)-4-methylphenol (BHEM), 2,6-bis-({2-[(3,4-dimethoxybenzylidene)amino]ethylimino} methyl)-4-methylphenol (BDEM) and 2,6-bis-({2-[(2,3,5-trichlorobenzylidene)amino]ethylimino}methyl)-4-methylphenol (BTEM), have been synthesized and characterized by analytical and spectral data. The data suggest that BHEM/BDEM/BTEM ligands afford square-pyramidal/distorted square-pyramidal geometry on metalation with Zn(II)/Cu(II). The binding behaviour of these complexes with DNA has been investigated using electronic absorption spectroscopy as well as viscosity and voltammetric measurements; the results show that they interact with DNA through intercalating way. From the DNA cleavage study of these complexes, investigated by gel electrophoresis, we found that they efficiently cleave supercoiled pUC19 DNA in the presence of a reducing agent (3-mercaptopropionic acid) and on irradiation with UV light of 360 nm wavelength. The mechanism reveals that singlet oxygen (1O2) plays a significant role in the photo cleavage. The superoxide dismutase (SOD) mimetic activity of the synthesized complexes demonstrates that most of the complexes have promising SOD-mimetic activity. The antimicrobial study indicates that the complexes inhibit the growth of bacteria and fungi more than the free ligands. [...]
Publisher

Journal
Year
Volume
8
Issue
1
Pages
96-107
Physical description
Dates
published
1 - 2 - 2010
online
16 - 2 - 2010
Contributors
  • Research Department of Chemistry, VHNSN College, Virudhunagar, 626001, India
  • Research Department of Chemistry, VHNSN College, Virudhunagar, 626001, India
References
  • [1] M. Shakir, N. Begum, Y. Azim, S. Parveen, Synth. React. Inorg. Met-Org. Chem. 33, 1367 (2003) http://dx.doi.org/10.1081/SIM-120024315[Crossref]
  • [2] B. Adhikari, A.K. Biswas, K. Nag, P. Zanello, A. Cinquantini, Polyhedron 6, 897 (1987) http://dx.doi.org/10.1016/S0277-5387(00)80931-6[Crossref]
  • [3] K.D. Karlin, Z. Tyeklar, In: G.L. Eichhorn, L. Marzilli (Eds.), Advances in Inorganic Biochemistry (Prentice Hall, Englewood Cliffs, NJ, 1994) Vol. 9
  • [4] K.D. Karluvi, Z. Tyeklar (Eds.), Bioinorganic Chemistry of Copper (Chapman and Hall, New York, 1993)
  • [5] A.M. Thomas, G. Neelakanta, S. Mahadevan, M. Nethaji, A.R. Chakravarty, Eur. J. Inorg. Chem. 2720 (2002)
  • [6] S.C. Zhang, Y. Shao, C. Tu, C.H. Dai, Z.J. Guo, Chin. J. Inorg. Chem. 20, 1159 (2004)
  • [7] Q.L. Li, et al., Bioorg. Med. Chem. 14, 4151 (2006) http://dx.doi.org/10.1016/j.bmc.2006.01.069[Crossref]
  • [8] S.G. Kang, G.R. Jeong, Inorg. Chem. Commun. 12, 62 (2009) http://dx.doi.org/10.1016/j.inoche.2008.11.004[Crossref]
  • [9] K.E. Erkkila, D.T. Odom, J.K. Barton, Chem. Rev. 99, 2777 (1999) http://dx.doi.org/10.1021/cr9804341[Crossref]
  • [10] L.J.K. Boerner, J.M. Zaleski, Curr. Opin. Chem. Biol. 9, 135 (2005) http://dx.doi.org/10.1016/j.cbpa.2005.02.010[Crossref]
  • [11] R. Bannet, Chemical Aspects of Photodynamic Therapy (Gorden and Breach, London, 2001)
  • [12] M.R. Detly, S.L. Gibson, S.J. Wagner, J. Med. Chem. 47, 3897 (2004) http://dx.doi.org/10.1021/jm040074b[Crossref]
  • [13] F.S. Mackay et al., Proc. Natl. Acad. Sci. USA 104, 207423 (2007) http://dx.doi.org/10.1073/pnas.0707742105[Crossref]
  • [14] L.C. Xu, S. Shi, J. Li, S.Y. Liao, K.C. Zheng, L.N. Ji, Dalton Trans. 291 (2008)
  • [15] A.K. Patra, T. Bhowmick, S. Ramakumar, A.R. Chakravarty, Inorg. Chem. 46, 9030 (2007) http://dx.doi.org/10.1021/ic701326z[Crossref]
  • [16] M.J. Fernandez, B. Wilson, M. Palacios, M.M. Rodrigo, K.B. Grant, A. Lorente, Bioconjugate Chem. 18, 121 (2007) http://dx.doi.org/10.1021/bc0601828[Crossref]
  • [17] D.D. Perrin, W.L.F. Armarego, D.R. Perrin, Purification of Laboratory Chemicals (Pergamon Press, Oxford, 1980)
  • [18] N. Raman, S.J. Raja, J. Joseph, J.D. Raja, J. Chil. Chem. Soc. 52, 1138 (2007) http://dx.doi.org/10.4067/S0717-97072007000200004[Crossref]
  • [19] A.D. Naik, V. K. Revankar, Indian J. Chem. 43A, 1447 (2004)
  • [20] N. Raman, A. Sakthivel, K. Rajasekaran, J. Coord. Chem. 62, 1661 (2009) http://dx.doi.org/10.1080/00958970802687554[Crossref]
  • [21] N.M. Aghatabay, Y. Mahmiani, H. Cevik, B. Dulger, Eur. J. Med. Chem. 44, 365 (2009) http://dx.doi.org/10.1016/j.ejmech.2008.02.038[Crossref]
  • [22] R.G. Bhirud, T.S. Srivastava, Inorg. Chim. Acta 173, 121 (1990) http://dx.doi.org/10.1016/S0020-1693(00)91063-6[Crossref]
  • [23] M.C.R. Arguelles et al., J. Inorg. Biochem. 103, 35 (2009) http://dx.doi.org/10.1016/j.jinorgbio.2008.08.015[Crossref]
  • [24] S. Niu, M. Zhao, R. Ren, S. Zhang, J. Inorg. Biochem. 103, 43 (2009) http://dx.doi.org/10.1016/j.jinorgbio.2008.09.001[Crossref]
  • [25] B.J. Hathaway, G. Wilkinson, R.D. Gillard, J.A. McCleverty, Comprehensive Coordination Chemistry (Pergamon Press, Oxford, UK, 1987) vol. 5
  • [26] U. Mukhopadhyay, I. Bernal, S.S. Massoud, F.A. Mautner, Inorg. Chim. Acta 357, 3673 (2004) http://dx.doi.org/10.1016/j.ica.2004.05.030[Crossref]
  • [27] S. Sathyanarayana, J.C. Daborusak, J.B. Chaires, Biochemistry 32, 2573 (1993) http://dx.doi.org/10.1021/bi00061a015[Crossref]
  • [28] A. Sitlani, E.C. Long, A.M. Pyle, J.K. Barton, J. Am. Chem. Soc. 114, 2303 (1992) http://dx.doi.org/10.1021/ja00033a003[Crossref]
  • [29] T.B. Thederahn, M.D. Kuwabara, T.A. Larsen, D.S. Sigman, J. Am. Chem. Soc. 111, 4941 (1989) http://dx.doi.org/10.1021/ja00195a057[Crossref]
  • [30] D.S. Sigman, A. Mazumder, D.M. Perrin, Chem. Rev. 93, 2295 (1993) http://dx.doi.org/10.1021/cr00022a011[Crossref]
  • [31] D.T. Sawyer, J.S. Valentine, Acc. Chem. Res. 14, 393 (1981) http://dx.doi.org/10.1021/ar00072a005[Crossref]
  • [32] M. Baudry, S. Etienne, A. Bruce, M. Palucki, E. Jacobsen, B. Malfroy, Biochem. Biophy. Res. Commun. 192, 964 (1993) http://dx.doi.org/10.1006/bbrc.1993.1509[Crossref]
  • [33] Z.H. Chohan, H. Pervez, A. Rauf, K.M. Khan, C.T. Supuran, J. Enzy, Inh. Med. Chem. 19, 417 (2004) http://dx.doi.org/10.1080/14756360410001710383[Crossref]
Document Type
Publication order reference
Identifiers
YADDA identifier
bwmeta1.element.-psjd-doi-10_2478_s11532-009-0103-2
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.