Synthesis and biological screening of octasubstituted-triphenodioxazines and its sulphur analogues with some novel intermediates

• Authors: Lalchand Heda , Chandresh Pareek , Dushyant Pareek , Sonraj Mosalpuri
• Languages of publication: EN

Abstracts

EN

Attempts have been made to prepare for the first time the octasubstituted-triphenodioxazines and triphenodithiazines heterocycles by cyclisation of 3,6-dichloro-2,5-bis(2′,4′,5′-trichloroanilino)-1,4-benzoquinone and condensation. This wasfollowed by cyclisation of substituted 2-aminobenzenethiol respectively with chloranil and bromanil in ethanolic solution of fused sodium acetate in the presence of benzoyl chloride in nitrobenzene. Their structures were confirmed on the basis of their chemical and spectral analyses. Moreover, the biological activity of these compounds was evaluated against the test organisms viz - E.coli, S. aureus, B. subtilis, M.luteus and C. albicans. These compounds synthesized from 2,4,5-trichloroaniline appeared to possess significant antimicrobial activities and an explicit correlation between structure and biological activity was also observed. [...]

Keywords

EN

Triphenodioxazines; Triphenodithiazine; Benzoquinones; Antimicrobial activity

• Publisher: De Gruyter Open
• Journal: Open Chemistry
• Year: 2010
• Volume: 8
• Issue: 1
• Pages: 51-57

Dates

published

1 - 2 - 2010

online

16 - 2 - 2010

Contributors

author

Lalchand Heda

• P. G. Research Laboratories, Department of Chemistry, S. D. Govt. College, 305901, Beawar, India

author

Chandresh Pareek

• P. G. Research Laboratories, Department of Chemistry, S. D. Govt. College, 305901, Beawar, India

author

Dushyant Pareek

• P. G. Research Laboratories, Department of Chemistry, S. D. Govt. College, 305901, Beawar, India

author

Sonraj Mosalpuri

• P. G. Research Laboratories, Department of Chemistry, S. D. Govt. College, 305901, Beawar, India

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Identifiers

DOI

10.2478/s11532-009-0100-5