Two charge-transfer complex spectrophotometric methods for the determination of sulpiride in pharmaceutical formulations

• Authors: Sayed Zayed
• Languages of publication: EN

Abstracts

EN

Two simple, rapid, accurate and sensitive spectrophotometric methods are described for the determination of sulpiride. They are based on charge transfer complexation between the drug as n-electron donor and p-chloranilic acid as π acceptor or iodine as σ-acceptor. These give highly coloured complexes with absorption maxima at 518 and 363, 294 nm, respectively. Beer’s law linear ranges were 13.7–341.4 and 1.7–20.5 µg mL−1 for the p-chloranilic acid and iodine methods. The methods were successfully applied to the determination of the drug in Dogmatil® Fort tablets and the results compared with the official method. The complex association constants and standard free energy changes were calculated using Benesi-Hildebrand plots. [...]

Keywords

EN

Spectrophotometric determination; Sulpiride; p-chloranilic acid; Iodine; Charge-transfer complexes

• Publisher: De Gruyter Open
• Journal: Open Chemistry
• Year: 2009
• Volume: 7
• Issue: 4
• Pages: 870-875

Dates

published

1 - 12 - 2009

online

6 - 10 - 2009

Contributors

author

Sayed Zayed

• Faculty of Industrial Education, Beni Suef University, 62511, Beni Suef, Egypt

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Identifiers

DOI

10.2478/s11532-009-0091-2