One step synthesis of Diflunisal using a Pd-diamine complex

• Authors: Tuula Kylmälä , Jan Tois , Youjun Xu , Robert Franzén
• Languages of publication: EN

Abstracts

EN

Diflunisal and Felbinac, two FDA-approved NSAIDs and other biphenyl carboxylic acids were prepared in one step by a simple and clean Suzuki cross-coupling reaction using an easily synthesized, air and moisture stable, palladium-diamine complex. The yield (93%) for the one-step preparation of Diflunisal is the best reported without using a glovebox and a phoshine-based catalyst. [...]

Keywords

EN

Diflunisal; Felbinac; NSAID; Biphenyl carboxylic acid; Suzuki cross-coupling; Pd-diamine complex

• Publisher: De Gruyter Open
• Journal: Open Chemistry
• Year: 2009
• Volume: 7
• Issue: 4
• Pages: 818-826

Dates

published

1 - 12 - 2009

online

6 - 10 - 2009

Contributors

author

Tuula Kylmälä

• Department of Chemistry and Bioengineering, Laboratory of Chemistry, Tampere University of Technology, Tampere, FIN-33720, Finland

author

Jan Tois

• Department of Chemistry and Bioengineering, Laboratory of Chemistry, Tampere University of Technology, Tampere, FIN-33720, Finland

author

Youjun Xu

• School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, 110016, China

author

Robert Franzén

• Department of Chemistry and Bioengineering, Laboratory of Chemistry, Tampere University of Technology, Tampere, FIN-33720, Finland

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Identifiers

DOI

10.2478/s11532-009-0068-1