RP-HPLC determination of lipophilicity in series of quinoline derivatives

• Authors: Robert Musiol , Josef Jampilek , Barbara Podeszwa , Jacek Finster , Dominik Tabak , Jiri Dohnal , Jaroslaw Polanski
• Languages of publication: EN

Abstracts

EN

In the present paper we describe results on the synthesis and lipophilicity determination of a series of biologically active compounds based on their heterocyclic structure. For synthesis of styrylquinoline-based compounds we applied microwave irradiation and solid phase techniques. The correlation between RP-HPLC retention parameter log k (the logarithm of retention factor k) and log P data calculated in various ways is discussed, as well as, the relationships between the lipophilicity and the chemical structure of the studied compounds. [...]

Keywords

EN

Lipophilicity; RP-HPLC; Microwave synthesis; Quinoline derivatives

• Publisher: De Gruyter Open
• Journal: Open Chemistry
• Year: 2009
• Volume: 7
• Issue: 3
• Pages: 586-597

Dates

published

1 - 9 - 2009

online

21 - 6 - 2009

Contributors

author

Robert Musiol

• Institute of Chemistry, University of Silesia, 40007, Katowice, Poland

author

Josef Jampilek

author

Barbara Podeszwa

• Institute of Chemistry, University of Silesia, 40007, Katowice, Poland

author

Jacek Finster

• Institute of Chemistry, University of Silesia, 40007, Katowice, Poland

author

Dominik Tabak

• Institute of Chemistry, University of Silesia, 40007, Katowice, Poland

author

Jiri Dohnal

author

Jaroslaw Polanski

• Institute of Chemistry, University of Silesia, 40007, Katowice, Poland

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Identifiers

DOI

10.2478/s11532-009-0059-2