Consequence of hydrogen atom abstraction from 5’-hydroxyl group of 2’-deoxyadenosine. Theoretical quantum mechanics study

• Authors: Bolesław Karwowski
• Languages of publication: EN

Abstracts

EN

Reactive oxygen species (ROS) may generate different nucleoside/nucleotide radicals in a cell environment. In this study, the possibility of cyclic-2’-deoxyadenosines formation by a rearrangement of their free radicals was investigated. It seems that for cyclic-nucleosides formation, adoption of an O4’-exo conformation by the sugar moiety is necessary. However, this is the energetically unfavoured form of the 2-deoxyribose ring. Moreover, the creation of a O5’, C8 bond in purine deoxy-nucleosides/nucleotides leads to the termination of the DNA elongation process. [...]

Keywords

EN

Tandem base lesion; DFT; Nucleoside/nucleotide modifications; Reactive oxygen species; Free radicals

• Publisher: De Gruyter Open
• Journal: Open Chemistry
• Year: 2008
• Volume: 6
• Issue: 3
• Pages: 450-455

Dates

published

1 - 9 - 2008

online

11 - 8 - 2008

Contributors

author

Bolesław Karwowski

• Department of Biopharmacy, Medical University of Lodz, 90-151, Lodz, Poland

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Identifiers

DOI

10.2478/s11532-008-0038-z