Microwave assisted reactions of 2-[3-(Trifluoromethyl)phenyl]-4-R1-furo[3,2-b] pyrrole-5-carboxhydrazides

• Authors: Renáta Gašparová , Martin Moncman , Branislav Horváth
• Languages of publication: EN

Abstracts

EN

The effect of microwave irradiation on the reactions of 2-[3-(trifluoromethyl)phenyl]-4-R1-furo[3,2-b]pyrrole-5-carboxhydrazides 1 with 5-arylfuran-2-carboxaldehydes 2, thiophene-2-carboxaldehyde (3) and methyl 2-formylfuro[3,2-b]pyrrole-5-carboxylates 4 has been studied. Reactions of 1 with formic and acetic acid, respectively, led to acylhydrazides 9a–c. Reaction of 1a with 4-substituted 1,3-oxazol-5(4H)-one 10 led to imidazole derivative 13. 1,2,4-Triazole-3-thiones 15a,b were synthesized by two-step reaction of 1a with potassium isothiocyanate and phenyl isothiocyanate, respectively, and subsequent base-catalyzed cyclization of thiosemicarbazides 14a,b. Pyrazole 16 was prepared by reaction of 1a with pentane-2,4-dione. [...]

Keywords

EN

Furo[3,2-b]pyrrole-5-carbochydrazide; Furan-2-carboxaldehyde; Five-membered heterocycles; Microwave irradiation

• Publisher: De Gruyter Open
• Journal: Open Chemistry
• Year: 2008
• Volume: 6
• Issue: 2
• Pages: 180-187

Dates

published

1 - 6 - 2008

online

17 - 4 - 2008

Contributors

author

Renáta Gašparová

• Department of Chemistry, Faculty of Natural Sciences, University of SS Cyril and Methodius, SK 917 01, Trnava, Slovak Republic

author

Martin Moncman

• Department of Chemistry, Faculty of Natural Sciences, University of SS Cyril and Methodius, SK 917 01, Trnava, Slovak Republic

author

Branislav Horváth

• Institute of Chemistry, Faculty of Natural Sciences, Comenius University, SK 842 15, Bratislava, Slovak Republic

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Identifiers

DOI

10.2478/s11532-008-0009-4